A Phase I study of the pharmacokinetics, safety and tolerability of a novel tocopheryl phosphate mixture/oxymorphone transdermal patch system

Characterize the pharmacokinetic profile and tolerability of two tocopheryl phosphate mixture/oxymorphone patch formulations in healthy subjects, and the active metabolite (6-OH-oxymorphone). Fifteen participants received a single application of oxymorphone patches +/− capsaicin for 72 h and were cr...

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Veröffentlicht in:	Pain management 2017-11, Vol.7 (6), p.499-512
Hauptverfasser:	Gavin, Paul D, Simon, Lee S, Schlagheck, Thomas, Smith, Alisha J, Krishnarajah, Janakan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult alpha-Tocopherol - adverse effects alpha-Tocopherol - analogs & derivatives alpha-Tocopherol - pharmacokinetics Analgesics, Opioid - adverse effects Analgesics, Opioid - blood Analgesics, Opioid - pharmacokinetics Bioavailability Capsaicin - adverse effects Capsaicin - pharmacokinetics Cross-Over Studies Dermatitis Drug Combinations Drug dosages Humans Male Metabolism Narcotics oxymorphone Oxymorphone - adverse effects Oxymorphone - blood Oxymorphone - pharmacokinetics Pain Pain management Pain Management - methods Patient compliance Pharmaceuticals Pharmacokinetics Pharmacology Skin tocopheryl phosphate mixture (TPM) Transdermal medication Transdermal Patch Young Adult
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