Catalytically Selective Chemotherapy from Tumor‐Metabolic Generated Lactic Acid

Lactic acid (LA) is a powerful molecule as the metabolic driver in tumor microenvironments (TMEs). Inspired by its high intratumoral level (5–20 µmol g−1), a novel treatment paradigm via the cascade release of H2O2 and ·OH from the LA generated by tumor metabolism is developed for catalytic and pH‐d...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2019-11, Vol.15 (46), p.e1903746-n/a
Hauptverfasser:	Tian, Zhimin, Yang, Kaili, Yao, Tianzhu, Li, Xuhui, Ma, Yuanyuan, Qu, Chaoyi, Qu, Xiaoli, Xu, Yujing, Guo, Yinhui, Qu, Yongquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cascade chemical reactions catalytic tumor chemotherapy cerium Chemotherapy Hydrogen peroxide Lactic acid Metabolism Metal-organic frameworks Nanotechnology Peroxidase reactive oxygen species tumor microenvironments Tumors
Online-Zugang:	Volltext
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