Exposure to ambient particulate matter induces oxidative stress in lung and aorta in a size- and time-dependent manner in rats

Exposure to particulate matter (PM) has been implicated in oxidative stress (OxS) and inflammation as underlying mechanisms of lung damage and cardiovascular alterations. PM is a chemical mixture that can be subdivided according to their aerodynamic size into coarse (CP), fine (FP), and ultrafine (U...

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Veröffentlicht in:	Toxicology Research and Application 2018-01, Vol.2
Hauptverfasser:	Aztatzi-Aguilar, OG, Valdés-Arzate, A, Debray-García, Y, Calderón-Aranda, ES, Uribe-Ramirez, M, Acosta-Saavedra, L, Gonsebatt, ME, Maciel-Ruiz, JA, Petrosyan, P, Mugica-Alvarez, V, Gutiérrez-Ruiz, MC, Gómez-Quiroz, LE, Osornio-Vargas, A, Froines, J, Kleinman, MT, De Vizcaya-Ruiz, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Airborne particulates Alveoli Antioxidants Aorta Bronchus Carcinogens Cardiovascular system Coronary vessels Cytokines Deoxyribonucleic acid DNA DNA adducts DNA damage Electrophoretic mobility Enzymes Exposure Gene expression Inflammation Interleukin 6 Interleukins Lungs Macrophage inflammatory protein mRNA Oxidants Oxidation Oxidative stress Oxidizing agents Particulate emissions Particulate matter Particulates Protein adducts Proteins Time dependence Ultrafines Vascular system
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