Severe hypersensitivity allergic reaction to filgrastim in a healthy stem cell donor
Introduction Granulocyte–colony stimulating factor (G-CSF) has been approved for use for mobilization of hematopoietic progenitor cells from the marrow into the blood for peripheral blood stem cell collection. Commonly reported side effects of G-CSF include deep throbbing bone pain, severe myalgia a...
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| Veröffentlicht in: | Journal of oncology pharmacy practice 2019-12, Vol.25 (8), p.2056-2058 |
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| container_title | Journal of oncology pharmacy practice |
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| creator | Doval, Divya Choudhary, Dharma Sharma, Sanjeev K Khandelwal, Vipin |
| description | Introduction
Granulocyte–colony stimulating factor (G-CSF) has been approved for use for mobilization of hematopoietic progenitor cells from the marrow into the blood for peripheral blood stem cell collection. Commonly reported side effects of G-CSF include deep throbbing bone pain, severe myalgia and leucocytosis.
Case report
We describe a case of severe hypersensitivity anaphylactoid reaction after filgrastim administration in a healthy stem cell donor. This haploidentical donor was a 38-year old man with sickle cell trait, donating stem cells for his son, a case of sickle cell disease. On administration of G-CSF (10 µg/kg) he developed features of anaphylaxis.
Management and outcome
He was given supportive care with oxygen, IV fluid bolus, anti histaminics and steroids. The donor had complete recovery and underwent successful bone marrow harvest.
Conclusion
There have been various reports of hypersensitivity anaphylactoid reactions in patients undergoing chemotherapy but those associated with the first dose of G-CSF in healthy stem cell donors have rarely been reported. |
| doi_str_mv | 10.1177/1078155219856419 |
| format | Article |
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Granulocyte–colony stimulating factor (G-CSF) has been approved for use for mobilization of hematopoietic progenitor cells from the marrow into the blood for peripheral blood stem cell collection. Commonly reported side effects of G-CSF include deep throbbing bone pain, severe myalgia and leucocytosis.
Case report
We describe a case of severe hypersensitivity anaphylactoid reaction after filgrastim administration in a healthy stem cell donor. This haploidentical donor was a 38-year old man with sickle cell trait, donating stem cells for his son, a case of sickle cell disease. On administration of G-CSF (10 µg/kg) he developed features of anaphylaxis.
Management and outcome
He was given supportive care with oxygen, IV fluid bolus, anti histaminics and steroids. The donor had complete recovery and underwent successful bone marrow harvest.
Conclusion
There have been various reports of hypersensitivity anaphylactoid reactions in patients undergoing chemotherapy but those associated with the first dose of G-CSF in healthy stem cell donors have rarely been reported.</description><identifier>ISSN: 1078-1552</identifier><identifier>EISSN: 1477-092X</identifier><identifier>DOI: 10.1177/1078155219856419</identifier><identifier>PMID: 31203715</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Anaphylactoid reactions ; Anaphylaxis ; Bone marrow ; Bone marrow transplantation ; Chemotherapy ; Colony-stimulating factor ; Drug Hypersensitivity - etiology ; Filgrastim - administration & dosage ; Filgrastim - adverse effects ; Granulocyte colony-stimulating factor ; Hematopoietic Stem Cell Mobilization ; Hematopoietic stem cells ; Hematopoietic Stem Cells - cytology ; Humans ; Hypersensitivity ; Leukocytes (granulocytic) ; Male ; Myalgia ; Pain - chemically induced ; Peripheral blood ; Progenitor cells ; Sickle cell disease ; Stem cell transplantation ; Stem cells ; Steroid hormones ; Steroids ; Tissue Donors</subject><ispartof>Journal of oncology pharmacy practice, 2019-12, Vol.25 (8), p.2056-2058</ispartof><rights>The Author(s) 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-5e08b20ed20ead6db712ff6de611f98452aeb5130b2f3bb61c87b1c3c127e6083</citedby><cites>FETCH-LOGICAL-c365t-5e08b20ed20ead6db712ff6de611f98452aeb5130b2f3bb61c87b1c3c127e6083</cites><orcidid>0000-0002-3511-0977</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1078155219856419$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1078155219856419$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31203715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doval, Divya</creatorcontrib><creatorcontrib>Choudhary, Dharma</creatorcontrib><creatorcontrib>Sharma, Sanjeev K</creatorcontrib><creatorcontrib>Khandelwal, Vipin</creatorcontrib><title>Severe hypersensitivity allergic reaction to filgrastim in a healthy stem cell donor</title><title>Journal of oncology pharmacy practice</title><addtitle>J Oncol Pharm Pract</addtitle><description>Introduction
Granulocyte–colony stimulating factor (G-CSF) has been approved for use for mobilization of hematopoietic progenitor cells from the marrow into the blood for peripheral blood stem cell collection. Commonly reported side effects of G-CSF include deep throbbing bone pain, severe myalgia and leucocytosis.
Case report
We describe a case of severe hypersensitivity anaphylactoid reaction after filgrastim administration in a healthy stem cell donor. This haploidentical donor was a 38-year old man with sickle cell trait, donating stem cells for his son, a case of sickle cell disease. On administration of G-CSF (10 µg/kg) he developed features of anaphylaxis.
Management and outcome
He was given supportive care with oxygen, IV fluid bolus, anti histaminics and steroids. The donor had complete recovery and underwent successful bone marrow harvest.
Conclusion
There have been various reports of hypersensitivity anaphylactoid reactions in patients undergoing chemotherapy but those associated with the first dose of G-CSF in healthy stem cell donors have rarely been reported.</description><subject>Adult</subject><subject>Anaphylactoid reactions</subject><subject>Anaphylaxis</subject><subject>Bone marrow</subject><subject>Bone marrow transplantation</subject><subject>Chemotherapy</subject><subject>Colony-stimulating factor</subject><subject>Drug Hypersensitivity - etiology</subject><subject>Filgrastim - administration & dosage</subject><subject>Filgrastim - adverse effects</subject><subject>Granulocyte colony-stimulating factor</subject><subject>Hematopoietic Stem Cell Mobilization</subject><subject>Hematopoietic stem cells</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Leukocytes (granulocytic)</subject><subject>Male</subject><subject>Myalgia</subject><subject>Pain - chemically induced</subject><subject>Peripheral blood</subject><subject>Progenitor cells</subject><subject>Sickle cell disease</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Steroid hormones</subject><subject>Steroids</subject><subject>Tissue Donors</subject><issn>1078-1552</issn><issn>1477-092X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UM1LwzAUD6I4nd49ScBzNS9tk_Qowy8YeHCCt5Kkr1tG184kG_S_t2NTQfDweA9-X7wfIVfAbgGkvAMmFeQ5h0LlIoPiiJxBJmXCCv5xPNwDnOzwETkPYckYU5KrUzJKgbNUQn5GZm-4RY900a_RB2yDi27rYk9106CfO0s9ahtd19LY0do1c69DdCvqWqrpAnUTFz0NEVfUYtPQqms7f0FOat0EvDzsMXl_fJhNnpPp69PL5H6a2FTkMcmRKcMZVsPoSlRGAq9rUaEAqAuV5VyjySFlhtepMQKskgZsaoFLFEylY3Kz91377nODIZbLbuPbIbLkw4uZUsDFwGJ7lvVdCB7rcu3dSvu-BFbuaiz_1jhIrg_GG7PC6kfw3dtASPaEoOf4m_qv4RfWsnpy</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Doval, Divya</creator><creator>Choudhary, Dharma</creator><creator>Sharma, Sanjeev K</creator><creator>Khandelwal, Vipin</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0002-3511-0977</orcidid></search><sort><creationdate>201912</creationdate><title>Severe hypersensitivity allergic reaction to filgrastim in a healthy stem cell donor</title><author>Doval, Divya ; Choudhary, Dharma ; Sharma, Sanjeev K ; Khandelwal, Vipin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-5e08b20ed20ead6db712ff6de611f98452aeb5130b2f3bb61c87b1c3c127e6083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Anaphylactoid reactions</topic><topic>Anaphylaxis</topic><topic>Bone marrow</topic><topic>Bone marrow transplantation</topic><topic>Chemotherapy</topic><topic>Colony-stimulating factor</topic><topic>Drug Hypersensitivity - etiology</topic><topic>Filgrastim - administration & dosage</topic><topic>Filgrastim - adverse effects</topic><topic>Granulocyte colony-stimulating factor</topic><topic>Hematopoietic Stem Cell Mobilization</topic><topic>Hematopoietic stem cells</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Humans</topic><topic>Hypersensitivity</topic><topic>Leukocytes (granulocytic)</topic><topic>Male</topic><topic>Myalgia</topic><topic>Pain - chemically induced</topic><topic>Peripheral blood</topic><topic>Progenitor cells</topic><topic>Sickle cell disease</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Steroid hormones</topic><topic>Steroids</topic><topic>Tissue Donors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doval, Divya</creatorcontrib><creatorcontrib>Choudhary, Dharma</creatorcontrib><creatorcontrib>Sharma, Sanjeev K</creatorcontrib><creatorcontrib>Khandelwal, Vipin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of oncology pharmacy practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doval, Divya</au><au>Choudhary, Dharma</au><au>Sharma, Sanjeev K</au><au>Khandelwal, Vipin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severe hypersensitivity allergic reaction to filgrastim in a healthy stem cell donor</atitle><jtitle>Journal of oncology pharmacy practice</jtitle><addtitle>J Oncol Pharm Pract</addtitle><date>2019-12</date><risdate>2019</risdate><volume>25</volume><issue>8</issue><spage>2056</spage><epage>2058</epage><pages>2056-2058</pages><issn>1078-1552</issn><eissn>1477-092X</eissn><abstract>Introduction
Granulocyte–colony stimulating factor (G-CSF) has been approved for use for mobilization of hematopoietic progenitor cells from the marrow into the blood for peripheral blood stem cell collection. Commonly reported side effects of G-CSF include deep throbbing bone pain, severe myalgia and leucocytosis.
Case report
We describe a case of severe hypersensitivity anaphylactoid reaction after filgrastim administration in a healthy stem cell donor. This haploidentical donor was a 38-year old man with sickle cell trait, donating stem cells for his son, a case of sickle cell disease. On administration of G-CSF (10 µg/kg) he developed features of anaphylaxis.
Management and outcome
He was given supportive care with oxygen, IV fluid bolus, anti histaminics and steroids. The donor had complete recovery and underwent successful bone marrow harvest.
Conclusion
There have been various reports of hypersensitivity anaphylactoid reactions in patients undergoing chemotherapy but those associated with the first dose of G-CSF in healthy stem cell donors have rarely been reported.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>31203715</pmid><doi>10.1177/1078155219856419</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-3511-0977</orcidid></addata></record> |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Adult Anaphylactoid reactions Anaphylaxis Bone marrow Bone marrow transplantation Chemotherapy Colony-stimulating factor Drug Hypersensitivity - etiology Filgrastim - administration & dosage Filgrastim - adverse effects Granulocyte colony-stimulating factor Hematopoietic Stem Cell Mobilization Hematopoietic stem cells Hematopoietic Stem Cells - cytology Humans Hypersensitivity Leukocytes (granulocytic) Male Myalgia Pain - chemically induced Peripheral blood Progenitor cells Sickle cell disease Stem cell transplantation Stem cells Steroid hormones Steroids Tissue Donors |
| title | Severe hypersensitivity allergic reaction to filgrastim in a healthy stem cell donor |
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