Estimation of heritability in myopic twin studies
Purpose To examine the genetic and environmental factors for myopia at the family level, as well as risk factors such as ocular measurements and environmental covariates at the individual level, by analysis of myopic twin data. Methods A myopic twin study was conducted on participants from the 2000...
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| Veröffentlicht in: | Japanese journal of ophthalmology 2009-11, Vol.53 (6), p.615-622 |
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| container_title | Japanese journal of ophthalmology |
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| creator | Tsai, Miao-Yu Lin, Luke L-K Lee, Vicky Chen, Chien-Jen Shih, Yung-Feng |
| description | Purpose
To examine the genetic and environmental factors for myopia at the family level, as well as risk factors such as ocular measurements and environmental covariates at the individual level, by analysis of myopic twin data.
Methods
A myopic twin study was conducted on participants from the 2000 Guinness World Records for twins in Taiwan. A total of 130 participants comprising 58 twin pairs and 13 siblings were recruited. The generalized estimating equation approach was used to evaluate the covariate effects. A Bayesian linear mixed model was then used to estimate the heritability.
Results
Pearson’s intrapairwise correlation coefficients for ocular refraction and its components were higher among monozygotic twins than among dizygotic twins. The significance of sex suggested that women are more myopic than men. Both axial length and anterior chamber depth were significant factors associated with myopia. The results also showed that people with higher education levels were more likely to have a higher degree of myopia. After accounting for genetic and environmental effects and other covariates, the estimate of heritability of myopia was as high as 0.306.
Conclusions
After adjusting for environmental covariates, heritability still plays a decisive genetic role in the development of myopia. |
| doi_str_mv | 10.1007/s10384-009-0724-1 |
| format | Article |
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To examine the genetic and environmental factors for myopia at the family level, as well as risk factors such as ocular measurements and environmental covariates at the individual level, by analysis of myopic twin data.
Methods
A myopic twin study was conducted on participants from the 2000 Guinness World Records for twins in Taiwan. A total of 130 participants comprising 58 twin pairs and 13 siblings were recruited. The generalized estimating equation approach was used to evaluate the covariate effects. A Bayesian linear mixed model was then used to estimate the heritability.
Results
Pearson’s intrapairwise correlation coefficients for ocular refraction and its components were higher among monozygotic twins than among dizygotic twins. The significance of sex suggested that women are more myopic than men. Both axial length and anterior chamber depth were significant factors associated with myopia. The results also showed that people with higher education levels were more likely to have a higher degree of myopia. After accounting for genetic and environmental effects and other covariates, the estimate of heritability of myopia was as high as 0.306.
Conclusions
After adjusting for environmental covariates, heritability still plays a decisive genetic role in the development of myopia.</description><identifier>ISSN: 0021-5155</identifier><identifier>EISSN: 1613-2246</identifier><identifier>DOI: 10.1007/s10384-009-0724-1</identifier><identifier>PMID: 20020241</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adult ; Clinical Investigation ; Diseases in Twins - genetics ; Educational Status ; Environment ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Myopia - genetics ; Ophthalmology ; Risk Factors ; Twins, Dizygotic ; Twins, Monozygotic</subject><ispartof>Japanese journal of ophthalmology, 2009-11, Vol.53 (6), p.615-622</ispartof><rights>Japanese Ophthalmological Society (JOS) 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-1ff40f960318c2899e2607f63c04f02e0034f1ee00716cb0d7c0f5d888d79e7a3</citedby><cites>FETCH-LOGICAL-c394t-1ff40f960318c2899e2607f63c04f02e0034f1ee00716cb0d7c0f5d888d79e7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10384-009-0724-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10384-009-0724-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20020241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsai, Miao-Yu</creatorcontrib><creatorcontrib>Lin, Luke L-K</creatorcontrib><creatorcontrib>Lee, Vicky</creatorcontrib><creatorcontrib>Chen, Chien-Jen</creatorcontrib><creatorcontrib>Shih, Yung-Feng</creatorcontrib><title>Estimation of heritability in myopic twin studies</title><title>Japanese journal of ophthalmology</title><addtitle>Jpn J Ophthalmol</addtitle><addtitle>Jpn J Ophthalmol</addtitle><description>Purpose
To examine the genetic and environmental factors for myopia at the family level, as well as risk factors such as ocular measurements and environmental covariates at the individual level, by analysis of myopic twin data.
Methods
A myopic twin study was conducted on participants from the 2000 Guinness World Records for twins in Taiwan. A total of 130 participants comprising 58 twin pairs and 13 siblings were recruited. The generalized estimating equation approach was used to evaluate the covariate effects. A Bayesian linear mixed model was then used to estimate the heritability.
Results
Pearson’s intrapairwise correlation coefficients for ocular refraction and its components were higher among monozygotic twins than among dizygotic twins. The significance of sex suggested that women are more myopic than men. Both axial length and anterior chamber depth were significant factors associated with myopia. The results also showed that people with higher education levels were more likely to have a higher degree of myopia. After accounting for genetic and environmental effects and other covariates, the estimate of heritability of myopia was as high as 0.306.
Conclusions
After adjusting for environmental covariates, heritability still plays a decisive genetic role in the development of myopia.</description><subject>Adult</subject><subject>Clinical Investigation</subject><subject>Diseases in Twins - genetics</subject><subject>Educational Status</subject><subject>Environment</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Myopia - genetics</subject><subject>Ophthalmology</subject><subject>Risk Factors</subject><subject>Twins, Dizygotic</subject><subject>Twins, Monozygotic</subject><issn>0021-5155</issn><issn>1613-2246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE9LAzEQxYMotlY_gBdZvEdnkuxmc5TiPyh40XPYZhNNaXdrkkX67U3ZqidPM_DevMf8CLlEuEEAeRsReC0ogKIgmaB4RKZYIaeMieqYTAEY0hLLckLOYlwBgGCcnZIJywowgVOC9zH5TZN83xW9Kz5s8KlZ-rVPu8J3xWbXb70p0lfeYxpab-M5OXHNOtqLw5yRt4f71_kTXbw8Ps_vFtRwJRJF5wQ4VQHH2rBaKcsqkK7iBoQDZgG4cGjzlFiZJbTSgCvbuq5bqaxs-Ixcj7nb0H8ONia96ofQ5UrNOKIoUUE24WgyoY8xWKe3Ib8TdhpB7xnpkZHOjPSekcZ8c3UIHpYb2_5e_EDJBjYaYpa6dxv-mv9P_QblDG-E</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Tsai, Miao-Yu</creator><creator>Lin, Luke L-K</creator><creator>Lee, Vicky</creator><creator>Chen, Chien-Jen</creator><creator>Shih, Yung-Feng</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20091101</creationdate><title>Estimation of heritability in myopic twin studies</title><author>Tsai, Miao-Yu ; Lin, Luke L-K ; Lee, Vicky ; Chen, Chien-Jen ; Shih, Yung-Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-1ff40f960318c2899e2607f63c04f02e0034f1ee00716cb0d7c0f5d888d79e7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Clinical Investigation</topic><topic>Diseases in Twins - genetics</topic><topic>Educational Status</topic><topic>Environment</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Myopia - genetics</topic><topic>Ophthalmology</topic><topic>Risk Factors</topic><topic>Twins, Dizygotic</topic><topic>Twins, Monozygotic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsai, Miao-Yu</creatorcontrib><creatorcontrib>Lin, Luke L-K</creatorcontrib><creatorcontrib>Lee, Vicky</creatorcontrib><creatorcontrib>Chen, Chien-Jen</creatorcontrib><creatorcontrib>Shih, Yung-Feng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Japanese journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsai, Miao-Yu</au><au>Lin, Luke L-K</au><au>Lee, Vicky</au><au>Chen, Chien-Jen</au><au>Shih, Yung-Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estimation of heritability in myopic twin studies</atitle><jtitle>Japanese journal of ophthalmology</jtitle><stitle>Jpn J Ophthalmol</stitle><addtitle>Jpn J Ophthalmol</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>53</volume><issue>6</issue><spage>615</spage><epage>622</epage><pages>615-622</pages><issn>0021-5155</issn><eissn>1613-2246</eissn><abstract>Purpose
To examine the genetic and environmental factors for myopia at the family level, as well as risk factors such as ocular measurements and environmental covariates at the individual level, by analysis of myopic twin data.
Methods
A myopic twin study was conducted on participants from the 2000 Guinness World Records for twins in Taiwan. A total of 130 participants comprising 58 twin pairs and 13 siblings were recruited. The generalized estimating equation approach was used to evaluate the covariate effects. A Bayesian linear mixed model was then used to estimate the heritability.
Results
Pearson’s intrapairwise correlation coefficients for ocular refraction and its components were higher among monozygotic twins than among dizygotic twins. The significance of sex suggested that women are more myopic than men. Both axial length and anterior chamber depth were significant factors associated with myopia. The results also showed that people with higher education levels were more likely to have a higher degree of myopia. After accounting for genetic and environmental effects and other covariates, the estimate of heritability of myopia was as high as 0.306.
Conclusions
After adjusting for environmental covariates, heritability still plays a decisive genetic role in the development of myopia.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>20020241</pmid><doi>10.1007/s10384-009-0724-1</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Clinical Investigation Diseases in Twins - genetics Educational Status Environment Female Humans Male Medicine Medicine & Public Health Myopia - genetics Ophthalmology Risk Factors Twins, Dizygotic Twins, Monozygotic |
| title | Estimation of heritability in myopic twin studies |
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