Relationships between the anti-HIV V3-derived peptide SPC3 and lymphocyte membrane properties involved in virus entry: SPC3 interferes with CXCR4
Abstract SPC3 is a multiple antigen peptide derived from the V3 loop of human immunodeficiency virus (HIV) envelope (Env). It exerts a potent anti-HIV activity whereas it alters neither Env expression nor binding to CD4. Here, SPC3 binding characteristics, its subsequent intracellular fate and the f...
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| Veröffentlicht in: | FEMS microbiology letters 2000-02, Vol.183 (2), p.235-240 |
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| container_title | FEMS microbiology letters |
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| creator | Barbouche, Rym Papandréou, Marie-Jeanne Miquelis, Raymond Guieu, Régis Fenouillet, Emmanuel |
| description | Abstract
SPC3 is a multiple antigen peptide derived from the V3 loop of human immunodeficiency virus (HIV) envelope (Env). It exerts a potent anti-HIV activity whereas it alters neither Env expression nor binding to CD4. Here, SPC3 binding characteristics, its subsequent intracellular fate and the fact that it inhibited SDF1α binding to the lymphocyte surface provided strong arguments to conclude that it exerts its anti-HIV activity through interference with the CXCR4 coreceptor. In contrast, it interferes with none of the other major surface proteins and mechanisms involving V3 and implicated in infection, as shown here. This work identifies the target mechanism of SPC3. |
| doi_str_mv | 10.1111/j.1574-6968.2000.tb08964.x |
| format | Article |
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SPC3 is a multiple antigen peptide derived from the V3 loop of human immunodeficiency virus (HIV) envelope (Env). It exerts a potent anti-HIV activity whereas it alters neither Env expression nor binding to CD4. Here, SPC3 binding characteristics, its subsequent intracellular fate and the fact that it inhibited SDF1α binding to the lymphocyte surface provided strong arguments to conclude that it exerts its anti-HIV activity through interference with the CXCR4 coreceptor. In contrast, it interferes with none of the other major surface proteins and mechanisms involving V3 and implicated in infection, as shown here. This work identifies the target mechanism of SPC3.</description><identifier>ISSN: 0378-1097</identifier><identifier>EISSN: 1574-6968</identifier><identifier>DOI: 10.1111/j.1574-6968.2000.tb08964.x</identifier><identifier>CODEN: FMLED7</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Antigens ; Antiviral activity ; Anti‐human immunodeficiency virus peptide ; Binding ; Biological and medical sciences ; CD4 antigen ; Coreceptor ; CXCR4 ; CXCR4 protein ; Fundamental and applied biological sciences. Psychology ; HIV ; Human immunodeficiency virus ; Human immunodeficiency virus entry ; Internalization ; Lymphocytes ; Microbiology ; Peptides ; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains ; Target recognition ; V3 loop ; Virology ; Viruses</subject><ispartof>FEMS microbiology letters, 2000-02, Vol.183 (2), p.235-240</ispartof><rights>2000 Federation of European Microbiological Societies 2000</rights><rights>2000 INIST-CNRS</rights><rights>2000 Federation of European Microbiological Societies</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1574-6968.2000.tb08964.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1574-6968.2000.tb08964.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1288854$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Barbouche, Rym</creatorcontrib><creatorcontrib>Papandréou, Marie-Jeanne</creatorcontrib><creatorcontrib>Miquelis, Raymond</creatorcontrib><creatorcontrib>Guieu, Régis</creatorcontrib><creatorcontrib>Fenouillet, Emmanuel</creatorcontrib><title>Relationships between the anti-HIV V3-derived peptide SPC3 and lymphocyte membrane properties involved in virus entry: SPC3 interferes with CXCR4</title><title>FEMS microbiology letters</title><description>Abstract
SPC3 is a multiple antigen peptide derived from the V3 loop of human immunodeficiency virus (HIV) envelope (Env). It exerts a potent anti-HIV activity whereas it alters neither Env expression nor binding to CD4. Here, SPC3 binding characteristics, its subsequent intracellular fate and the fact that it inhibited SDF1α binding to the lymphocyte surface provided strong arguments to conclude that it exerts its anti-HIV activity through interference with the CXCR4 coreceptor. In contrast, it interferes with none of the other major surface proteins and mechanisms involving V3 and implicated in infection, as shown here. This work identifies the target mechanism of SPC3.</description><subject>Antigens</subject><subject>Antiviral activity</subject><subject>Anti‐human immunodeficiency virus peptide</subject><subject>Binding</subject><subject>Biological and medical sciences</subject><subject>CD4 antigen</subject><subject>Coreceptor</subject><subject>CXCR4</subject><subject>CXCR4 protein</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Human immunodeficiency virus entry</subject><subject>Internalization</subject><subject>Lymphocytes</subject><subject>Microbiology</subject><subject>Peptides</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>Target recognition</subject><subject>V3 loop</subject><subject>Virology</subject><subject>Viruses</subject><issn>0378-1097</issn><issn>1574-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kcFu1DAURSMEEkPpP1jANqnt2InNAglFlFYaBCq0YmfZyYvGo4wTbM9M8xn9YxzNCDbgjRfv3Gs_nSx7Q3BB0rnaFoTXLK9kJQqKMS6iwUJWrHh8lq3-jJ5nK1zWIidY1i-zVyFsE8oorlbZ0x0MOtrRhY2dAjIQjwAOxQ0g7aLNb24f0EOZd-DtATo0wRRtB-j7t6ZMQIeGeTdtxnaOgHawM147QJMfJ_DRQkDWHcZhCVqHDtbvAwIX_fz-VGBdBN-DT-DRxg1qfjZ37HX2otdDgMvzfZHdX3_60dzk66-fb5uP63wkXPC87UtiJMXQmYpUknWG1z0IkxYTuJKyhqplFaa1NsCJZlJgyijTDCQH2pryInt76k3f_bWHENV23HuXnlS0JGTpwDJR786UDq0e-rRga4OavN1pPytChRCcJezDCTvaAea_Y6wWTWqrFhdqcaEWTeqsST2q6y9rWvJUwE8F4376Tzz_R7z8DU6WmWw</recordid><startdate>200002</startdate><enddate>200002</enddate><creator>Barbouche, Rym</creator><creator>Papandréou, Marie-Jeanne</creator><creator>Miquelis, Raymond</creator><creator>Guieu, Régis</creator><creator>Fenouillet, Emmanuel</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Oxford University Press</general><scope>IQODW</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope></search><sort><creationdate>200002</creationdate><title>Relationships between the anti-HIV V3-derived peptide SPC3 and lymphocyte membrane properties involved in virus entry: SPC3 interferes with CXCR4</title><author>Barbouche, Rym ; Papandréou, Marie-Jeanne ; Miquelis, Raymond ; Guieu, Régis ; Fenouillet, Emmanuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-o1585-cf31b920edb61694db57fe8b004806997e6c46027abe51a49802424a4e95e2cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Antigens</topic><topic>Antiviral activity</topic><topic>Anti‐human immunodeficiency virus peptide</topic><topic>Binding</topic><topic>Biological and medical sciences</topic><topic>CD4 antigen</topic><topic>Coreceptor</topic><topic>CXCR4</topic><topic>CXCR4 protein</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Human immunodeficiency virus entry</topic><topic>Internalization</topic><topic>Lymphocytes</topic><topic>Microbiology</topic><topic>Peptides</topic><topic>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</topic><topic>Target recognition</topic><topic>V3 loop</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barbouche, Rym</creatorcontrib><creatorcontrib>Papandréou, Marie-Jeanne</creatorcontrib><creatorcontrib>Miquelis, Raymond</creatorcontrib><creatorcontrib>Guieu, Régis</creatorcontrib><creatorcontrib>Fenouillet, Emmanuel</creatorcontrib><collection>Pascal-Francis</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><jtitle>FEMS microbiology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barbouche, Rym</au><au>Papandréou, Marie-Jeanne</au><au>Miquelis, Raymond</au><au>Guieu, Régis</au><au>Fenouillet, Emmanuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationships between the anti-HIV V3-derived peptide SPC3 and lymphocyte membrane properties involved in virus entry: SPC3 interferes with CXCR4</atitle><jtitle>FEMS microbiology letters</jtitle><date>2000-02</date><risdate>2000</risdate><volume>183</volume><issue>2</issue><spage>235</spage><epage>240</epage><pages>235-240</pages><issn>0378-1097</issn><eissn>1574-6968</eissn><coden>FMLED7</coden><abstract>Abstract
SPC3 is a multiple antigen peptide derived from the V3 loop of human immunodeficiency virus (HIV) envelope (Env). It exerts a potent anti-HIV activity whereas it alters neither Env expression nor binding to CD4. Here, SPC3 binding characteristics, its subsequent intracellular fate and the fact that it inhibited SDF1α binding to the lymphocyte surface provided strong arguments to conclude that it exerts its anti-HIV activity through interference with the CXCR4 coreceptor. In contrast, it interferes with none of the other major surface proteins and mechanisms involving V3 and implicated in infection, as shown here. This work identifies the target mechanism of SPC3.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><doi>10.1111/j.1574-6968.2000.tb08964.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | FEMS microbiology letters, 2000-02, Vol.183 (2), p.235-240 |
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| source | Oxford University Press Journals All Titles (1996-Current); Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Antigens Antiviral activity Anti‐human immunodeficiency virus peptide Binding Biological and medical sciences CD4 antigen Coreceptor CXCR4 CXCR4 protein Fundamental and applied biological sciences. Psychology HIV Human immunodeficiency virus Human immunodeficiency virus entry Internalization Lymphocytes Microbiology Peptides Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Target recognition V3 loop Virology Viruses |
| title | Relationships between the anti-HIV V3-derived peptide SPC3 and lymphocyte membrane properties involved in virus entry: SPC3 interferes with CXCR4 |
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