Evidence for intermolecular interaction as a necessary step for pore-formation activity and toxicity of Bacillus thuringiensis Cry1Ab toxin

Abstract Based on the observation of large conductance states formed by Bacillus thuringiensis Cry toxins in synthetic planar lipid bilayers and the estimation of a pore size of 10–20 Å, it has been proposed that the pore could be formed by an oligomer containing four to six Cry toxin monomers. Howe...

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Veröffentlicht in:	FEMS microbiology letters 2000-10, Vol.191 (2), p.221-225
Hauptverfasser:	Soberón, Mario, Pérez, Rigoberto V., Nuñez-Valdéz, María E., Lorence, Argelia, Gómez, Isabel, Sánchez, Jorge, Bravo, Alejandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacillus thuringiensis Binding Conductance Cry1Ab toxin Fluorescent dyes Fluorescent indicators Larvae Lipid bilayers Lipids Manduca sexta Membrane vesicles Membranes Microbiology Mode of action Monomers Oligomers Pore formation Pore size Porosity Proteins Resistance Toxicity Toxins Vesicles δ‐Endotoxin oligomerization
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