Effect of IS01957, a para‐coumaric acid derivative on pharmacokinetic modulation of diclofenac through oral route for augmented efficacy

Diclofenac is one of the world's largest selling nonsteroidal anti‐inflammatory drugs. The major concerns related to oral diclofenac therapy are gastrointestinal and cardiovascular side effects for which explicitly emphasis has been given to use it at lowest effective dose for the shortest dura...

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Veröffentlicht in:	Drug development research 2019-11, Vol.80 (7), p.948-957
Hauptverfasser:	Sharma, Anjna, Gour, Abhishek, Bhatt, Shipra, Rath, Santosh K., Malik, Tanveer A., Dogra, Ashish, Sangwan, Payare L., Koul, Surrinder, Abdullah, Sheikh Tasduq, Singh, Gurdarshan, Nandi, Utpal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Adenosine Triphosphatases - antagonists & inhibitors Administration, Oral Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anti-Inflammatory Agents, Non-Steroidal - pharmacology Bioavailability bioenhancer Coumaric acid Cytochrome P-450 CYP2C9 - metabolism Diclofenac Diclofenac - pharmacokinetics Diclofenac - pharmacology Dinoprostone - metabolism Drug Interactions Drug Synergism Effectiveness Female Gastric Mucosa - metabolism Hydroxylation Hydroxylation - drug effects Immunoblotting Inflammation Intestine IS01957 Liabilities Male MAP kinase MAP Kinase Signaling System - drug effects Mice Microsomes Microsomes, Liver - metabolism Modulation Morpholines - administration & dosage Morpholines - pharmacology Nonsteroidal anti-inflammatory drugs Oral administration Pain perception Perfusion Permeability Permeability - drug effects Pharmacodynamics Pharmacokinetics Pharmacology Prostaglandin E2 Rats Side effects
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