Specificity, strength, and evolution of pretransplant donor‐specific HLA antibodies determine outcome after kidney transplantation

In this cohort study (N = 924), we investigated the evolution and clinical significance of pretransplant donor‐specific HLA antibodies (preDSA), detected in the single‐antigen beads assay but complement‐dependent cytotoxicity crossmatch‐negative. Donor specificity of the preDSA (N = 107) was determi...

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Veröffentlicht in:	American journal of transplantation 2019-11, Vol.19 (11), p.3100-3113
Hauptverfasser:	Senev, Aleksandar, Lerut, Evelyne, Van Sandt, Vicky, Coemans, Maarten, Callemeyn, Jasper, Sprangers, Ben, Kuypers, Dirk, Emonds, Marie‐Paule, Naesens, Maarten
Format:	Artikel
Sprache:	eng
Schlagworte:	alloantibody Antibodies antibody‐mediated (ABMR) clinical research/practice Cohort Studies Cytotoxicity deceased donors and donation Female Follow-Up Studies Genotyping Graft rejection Graft Rejection - etiology Graft Rejection - mortality Graft Rejection - pathology Graft Survival Grafts health services and outcomes research histocompatibility Histocompatibility antigen HLA Histocompatibility testing HLA Antigens - immunology Humans Isoantibodies - adverse effects Kidney Failure, Chronic - surgery Kidney transplantation Kidney Transplantation - adverse effects kidney transplantation/nephrology Kidney transplants major histocompatibility complex (MHC) Male Middle Aged organ procurement and allocation Prognosis rejection risk assessment/risk stratification Risk Factors ROC Curve Survival Tissue Donors - supply & distribution
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