BldD from Streptomyces coelicolor is a non-essential global regulator that binds its own promoter as a dimer
We have shown that the bldD gene of Streptomyces coelicolor, while required for antibiotic production and morphological differentiation, is not essential for viability. We have also demonstrated that BldD forms a higher order complex both in solution and when bound to target DNA. Purified BldD exist...
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| Veröffentlicht in: | FEMS microbiology letters 2003-08, Vol.225 (1), p.35-40 |
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| container_title | FEMS microbiology letters |
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| creator | Elliot, Marie A Locke, Troy R Galibois, Claire M Leskiw, Brenda K |
| description | We have shown that the bldD gene of Streptomyces coelicolor, while required for antibiotic production and morphological differentiation, is not essential for viability. We have also demonstrated that BldD forms a higher order complex both in solution and when bound to target DNA. Purified BldD exists in three forms in solution, as a tetramer, dimer and monomer, but only in the dimeric form when bound to its own promoter/operator. |
| doi_str_mv | 10.1016/S0378-10970300474-9 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0378-1097 |
| ispartof | FEMS microbiology letters, 2003-08, Vol.225 (1), p.35-40 |
| issn | 0378-1097 1574-6968 |
| language | eng |
| recordid | cdi_proquest_journals_2309372747 |
| source | Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Antibiotics Deoxyribonucleic acid Dimers DNA Microbiology Streptomyces coelicolor Viability |
| title | BldD from Streptomyces coelicolor is a non-essential global regulator that binds its own promoter as a dimer |
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