Application of Hot Melt Extrusion for the Solubility Enhancement of a BCS Class II Drug

Application of Hot Melt Extrusion for the Solubility Enhancement of a BCS Class II Drug

Solubility enhancement of poorly soluble drugs for improved oral absorption has become a challenging task for the scientists in the development of pharmaceuticals. The main goal of this study is to investigate the effect of the hydrophilic polymers on the poorly water soluble drug to enhance its sol...

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Veröffentlicht in:Research journal of pharmacy and technology 2019-08, Vol.12 (8), p.3751-3754
Hauptverfasser: Kumar, Ashay Manisha Shailendra, Kulyadi, Girish Pai, Mutalik, Srinivas, Kulkarni, Vijay Induvadan, Tippavajhala, Vamshi Krishna
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Sprache:eng
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Analgesics
Bioavailability
Drug dosages
Pharmaceutical industry
Polymers
Solvents
Studies
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container_issue 8
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container_title Research journal of pharmacy and technology
container_volume 12
creator Kumar, Ashay Manisha Shailendra
Kulyadi, Girish Pai
Mutalik, Srinivas
Kulkarni, Vijay Induvadan
Tippavajhala, Vamshi Krishna
description Solubility enhancement of poorly soluble drugs for improved oral absorption has become a challenging task for the scientists in the development of pharmaceuticals. The main goal of this study is to investigate the effect of the hydrophilic polymers on the poorly water soluble drug to enhance its solubility through the technique of hotmelt extrusion. The drug selected for this study is paracetamol and the hydrophilic polymers selected for this study are polyox, carbopol 980p, and PEG 6000. The drug and the polymer at a ratio of 1:2 was processed through STEERLife twin screw extruder. The obtained solid dispersion was subjected to the saturation solubility study. Among the selected polymers, paracetamol with polyox polymer has shown enhanced solubility followed by PEG 6000 and carbopol 980p.
doi_str_mv 10.5958/0974-360X.2019.00642.5
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subjects Analgesics
Bioavailability
Drug dosages
Pharmaceutical industry
Polymers
Solvents
Studies
title Application of Hot Melt Extrusion for the Solubility Enhancement of a BCS Class II Drug
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