A CMOS Electrochemical Biochip With 32[Formula Omitted]32 Three-Electrode Voltammetry Pixels
A CMOS-integrated electrochemical biochip for high-performance molecular testing is presented. The system includes an array of 32[Formula Omitted]32 three-electrode voltammetry pixels and on-chip temperature control between 25 and 95 °C. Each 100 [Formula Omitted] pixel includes a CMOS-compatible an...
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| Veröffentlicht in: | IEEE journal of solid-state circuits 2019-11, Vol.54 (11), p.2980 |
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| container_issue | 11 |
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| container_title | IEEE journal of solid-state circuits |
| container_volume | 54 |
| creator | Manickam, Arun You, Kae-Dyi Wood, Nicholas Pei, Lei Liu, Yang Singh, Rituraj Nader Gamini McDermott, Mark W Shahrjerdi, Davood Kuimelis, Robert G Hassibi, Arjang |
| description | A CMOS-integrated electrochemical biochip for high-performance molecular testing is presented. The system includes an array of 32[Formula Omitted]32 three-electrode voltammetry pixels and on-chip temperature control between 25 and 95 °C. Each 100 [Formula Omitted] pixel includes a CMOS-compatible and chemo-stable amorphous carbon electrode transducer connected to in-pixel [Formula Omitted] current detection circuitry with 280 fA rms input-referred noise (0.1–20 Hz bandwidth) and 93 dB dynamic range (DR). Array-based DNA detection assays are implemented, and successful DNA melt-analysis and real-time label-free DNA hybridization detection are reported. |
| doi_str_mv | 10.1109/JSSC.2019.2941020 |
| format | Article |
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The system includes an array of 32[Formula Omitted]32 three-electrode voltammetry pixels and on-chip temperature control between 25 and 95 °C. Each 100 [Formula Omitted] pixel includes a CMOS-compatible and chemo-stable amorphous carbon electrode transducer connected to in-pixel [Formula Omitted] current detection circuitry with 280 fA rms input-referred noise (0.1–20 Hz bandwidth) and 93 dB dynamic range (DR). Array-based DNA detection assays are implemented, and successful DNA melt-analysis and real-time label-free DNA hybridization detection are reported.</description><identifier>ISSN: 0018-9200</identifier><identifier>EISSN: 1558-173X</identifier><identifier>DOI: 10.1109/JSSC.2019.2941020</identifier><language>eng</language><publisher>New York: The Institute of Electrical and Electronics Engineers, Inc. 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(IEEE)</general><scope>7SP</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20191101</creationdate><title>A CMOS Electrochemical Biochip With 32[Formula Omitted]32 Three-Electrode Voltammetry Pixels</title><author>Manickam, Arun ; You, Kae-Dyi ; Wood, Nicholas ; Pei, Lei ; Liu, Yang ; Singh, Rituraj ; Nader Gamini ; McDermott, Mark W ; Shahrjerdi, Davood ; Kuimelis, Robert G ; Hassibi, Arjang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p98t-4cbe867e3a3cfe761297e0a25e005c20b989411e250d32ba11b168989855e1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Arrays</topic><topic>Biochips</topic><topic>Circuits</topic><topic>CMOS</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Electrodes</topic><topic>Noise levels</topic><topic>Pixels</topic><topic>Temperature control</topic><topic>Voltammetry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manickam, Arun</creatorcontrib><creatorcontrib>You, Kae-Dyi</creatorcontrib><creatorcontrib>Wood, Nicholas</creatorcontrib><creatorcontrib>Pei, Lei</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Singh, Rituraj</creatorcontrib><creatorcontrib>Nader Gamini</creatorcontrib><creatorcontrib>McDermott, Mark W</creatorcontrib><creatorcontrib>Shahrjerdi, Davood</creatorcontrib><creatorcontrib>Kuimelis, Robert G</creatorcontrib><creatorcontrib>Hassibi, Arjang</creatorcontrib><collection>Electronics & Communications Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>IEEE journal of solid-state circuits</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manickam, Arun</au><au>You, Kae-Dyi</au><au>Wood, Nicholas</au><au>Pei, Lei</au><au>Liu, Yang</au><au>Singh, Rituraj</au><au>Nader Gamini</au><au>McDermott, Mark W</au><au>Shahrjerdi, Davood</au><au>Kuimelis, Robert G</au><au>Hassibi, Arjang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A CMOS Electrochemical Biochip With 32[Formula Omitted]32 Three-Electrode Voltammetry Pixels</atitle><jtitle>IEEE journal of solid-state circuits</jtitle><date>2019-11-01</date><risdate>2019</risdate><volume>54</volume><issue>11</issue><spage>2980</spage><pages>2980-</pages><issn>0018-9200</issn><eissn>1558-173X</eissn><abstract>A CMOS-integrated electrochemical biochip for high-performance molecular testing is presented. 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| source | IEEE Electronic Library (IEL) |
| subjects | Arrays Biochips Circuits CMOS Deoxyribonucleic acid DNA Electrodes Noise levels Pixels Temperature control Voltammetry |
| title | A CMOS Electrochemical Biochip With 32[Formula Omitted]32 Three-Electrode Voltammetry Pixels |
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