A CMOS Electrochemical Biochip With 32[Formula Omitted]32 Three-Electrode Voltammetry Pixels

A CMOS-integrated electrochemical biochip for high-performance molecular testing is presented. The system includes an array of 32[Formula Omitted]32 three-electrode voltammetry pixels and on-chip temperature control between 25 and 95 °C. Each 100 [Formula Omitted] pixel includes a CMOS-compatible an...

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Veröffentlicht in:IEEE journal of solid-state circuits 2019-11, Vol.54 (11), p.2980
Hauptverfasser: Manickam, Arun, You, Kae-Dyi, Wood, Nicholas, Pei, Lei, Liu, Yang, Singh, Rituraj, Nader Gamini, McDermott, Mark W, Shahrjerdi, Davood, Kuimelis, Robert G, Hassibi, Arjang
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Sprache:eng
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Zusammenfassung:A CMOS-integrated electrochemical biochip for high-performance molecular testing is presented. The system includes an array of 32[Formula Omitted]32 three-electrode voltammetry pixels and on-chip temperature control between 25 and 95 °C. Each 100 [Formula Omitted] pixel includes a CMOS-compatible and chemo-stable amorphous carbon electrode transducer connected to in-pixel [Formula Omitted] current detection circuitry with 280 fA rms input-referred noise (0.1–20 Hz bandwidth) and 93 dB dynamic range (DR). Array-based DNA detection assays are implemented, and successful DNA melt-analysis and real-time label-free DNA hybridization detection are reported.
ISSN:0018-9200
1558-173X
DOI:10.1109/JSSC.2019.2941020