Aromatase-induced endogenous estrogen promotes tumour metastasis through estrogen receptor-α/matrix metalloproteinase 12 axis activation in castration-resistant prostate cancer

Castration-resistant prostate cancer (CRPC) following androgen deprivation therapy remains a major obstacle advanced prostate cancer management. Aromatase catalyzes estrogen from androgens, yet the role of aromatase-generated endogenous estrogen in CRPC is poorly understood. In this study, we assess...

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Veröffentlicht in:	Cancer letters 2019-12, Vol.467, p.72-84
Hauptverfasser:	Liang, Zhixian, Cao, Jiasong, Tian, Lei, Shen, Yongmei, Yang, Xu, Lin, Qimei, Zhang, Ran, Liu, Haitao, Du, Xiaoling, Shi, Jiandang, Zhang, Ju
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Age Aged Androgen independence prostate cancer Androgens Anilides - administration & dosage Anilides - pharmacology Animals Aromatase Aromatase - genetics Aromatase - metabolism Bioinformatics Bone marrow Castration CD44 CD44 antigen Cell adhesion & migration Cell Line, Tumor Cell membranes CYP19A1 Datasets Endogenous estrogenic effects Epithelial-Mesenchymal Transition Estrogen Receptor alpha - metabolism Estrogens Estrogens - metabolism Gene expression Gene Expression Regulation, Neoplastic - drug effects Humans Hyaluronan Receptors - metabolism Invasiveness Letrozole - administration & dosage Letrozole - pharmacology Male Matrix metalloproteinase Matrix Metalloproteinase 12 - genetics Medical research Menopause Mesenchyme Metalloproteinase Metastases Metastasis Mice Middle Aged MMP12 Neoplasm Metastasis Nitriles - administration & dosage Nitriles - pharmacology PC-3 Cells Prostate cancer Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - genetics Prostatic Neoplasms, Castration-Resistant - metabolism Prostatic Neoplasms, Castration-Resistant - pathology Sex hormones Software Stem cells Therapeutic applications Tosyl Compounds - administration & dosage Tosyl Compounds - pharmacology Tumor cell lines Tumors Up-Regulation - drug effects Urology Xenografts
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