Genomic insights into the evolution and ecology of botulinum neurotoxins

Abstract Clostridial neurotoxins, which include botulinum neurotoxins (BoNTs) and tetanus neurotoxins, have evolved a remarkably sophisticated structure and molecular mechanism fine-tuned for the targeting and cleavage of vertebrate neuron substrates leading to muscular paralysis. How and why did th...

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Veröffentlicht in:	Pathogens and disease 2018-06, Vol.76 (4)
Hauptverfasser:	Mansfield, Michael J, Doxey, Andrew C
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Chryseobacterium - classification Chryseobacterium - genetics Chryseobacterium - pathogenicity Clostridium botulinum - classification Clostridium botulinum - genetics Clostridium botulinum - pathogenicity Clostridium tetani - classification Clostridium tetani - genetics Clostridium tetani - pathogenicity Domains Ecology Enterococcus - classification Enterococcus - genetics Enterococcus - pathogenicity Evolution Evolution, Molecular Gene Expression Regulation, Bacterial Genetic Loci Genome, Bacterial Genomes Homology Host-Pathogen Interactions Humans Metalloendopeptidases - biosynthesis Metalloendopeptidases - genetics Molecular structure Multigene Family Neurotoxins Paralysis Phylogeny Proteins Serotypes SNAP-25 protein Substrates Tetanus Tetanus Toxin - biosynthesis Tetanus Toxin - genetics Toxins Vertebrates Weissella - classification Weissella - genetics Weissella - pathogenicity
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