Rh( iii )-Catalyzed C–H activation/annulation of salicylaldehydes with sulfoxonium ylides for the synthesis of chromones
A rhodium( iii )-catalyzed C–H activation/annulation of salicylaldehydes with sulfoxonium ylides has been developed for the formation of 2-substituted chromones in good yields with broad functional group tolerance. The utility of this strategy was showcased by the late-stage modification of some bio...
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| Veröffentlicht in: | Organic Chemistry Frontiers 2019-11, Vol.6 (21), p.3688-3692 |
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| container_issue | 21 |
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| container_title | Organic Chemistry Frontiers |
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| creator | Cai, Libo Zhu, Xiaoyi Chen, Jiayi Lin, Aijun Yao, Hequan |
| description | A rhodium(
iii
)-catalyzed C–H activation/annulation of salicylaldehydes with sulfoxonium ylides has been developed for the formation of 2-substituted chromones in good yields with broad functional group tolerance. The utility of this strategy was showcased by the late-stage modification of some biologically active molecules. Moreover, structurally diverse 2,3-disubstituted chromones were also constructed by the C3 C–H functionalization reactions. |
| doi_str_mv | 10.1039/C9QO00830F |
| format | Article |
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| identifier | ISSN: 2052-4129 |
| ispartof | Organic Chemistry Frontiers, 2019-11, Vol.6 (21), p.3688-3692 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Activation Biological activity Chemical reactions Functional groups NMR Nuclear magnetic resonance Organic chemistry Rhodium |
| title | Rh( iii )-Catalyzed C–H activation/annulation of salicylaldehydes with sulfoxonium ylides for the synthesis of chromones |
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