Resistance to activation-induced cell death and elevated FLIPL expression of CD4+ T cells in a polyI:C-induced primary biliary cirrhosis mouse model

Primary biliary cirrhosis (PBC) is a type of organ-specific autoimmune disease in which immune tolerance is impaired by an unknown mechanism. We established a PBC animal model by injecting C57BL/6 mice with polyI:C to study activation-induced cell death (AICD) in CD4+ T lymphocytes and changes of ap...

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Veröffentlicht in:	Clinical and experimental medicine 2009-12, Vol.9 (4), p.269-276
Hauptverfasser:	Jiang, Tingwang, Han, Zhijun, Chen, Sunxiao, Wu, Chuanyong, Tang, Yujie, Qian, Cheng, Chen, Yan, Zhou, Ye, Zhu, Ye, Gu, Mingli, Zhu, Liang, Yao, Dingkang, Deng, Anmei, Zhong, Renqian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Autoimmune diseases Blotting, Western CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism CD4-Positive T-Lymphocytes - immunology Disease Models, Animal Fas Ligand Protein - genetics Fas Ligand Protein - metabolism Female Hematology Interferon Inducers - toxicity Internal Medicine Liver cirrhosis Liver Cirrhosis, Biliary - chemically induced Liver Cirrhosis, Biliary - immunology Lymphocyte Activation Medicine Medicine & Public Health Mice Mice, Inbred C57BL Oncology Original Article Poly I-C - toxicity Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Rodents TNF-Related Apoptosis-Inducing Ligand - genetics TNF-Related Apoptosis-Inducing Ligand - metabolism
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