Changes in the content of molecular chaperone Hsp60 in heart tissue at dilated cardiomyopathy
The changes of Hsp60 content in heart tissue at dilated cardiomyopathy (DCM) were investigated. An increase in Hsp60 level was observed in human hearts affected by DCM as well as in the hearts of mice with disease model similar to human DCM. We observed the increase in Hsp60 level in mitochondria an...
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| Veröffentlicht in: | Biopolimery i kletka 2008-05, Vol.24 (3), p.238-245 |
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| container_title | Biopolimery i kletka |
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| creator | Kapustian, L. M. Rozhko, O. T. Bobyk, V. I. Kroupska, I. V. Riabenko, D. V. Khozhaenko, Yu. S. Gurtovyy, V. A. Usenko, V. S. Sidorik, L. L. |
| description | The changes of Hsp60 content in heart tissue at dilated cardiomyopathy (DCM) were investigated. An increase in Hsp60 level was observed in human hearts affected by DCM as well as in the hearts of mice with disease model similar to human DCM. We observed the increase in Hsp60 level in mitochondria and decrease in cytoplasmic fraction, which could be one of the reasons for apoptotic responce in cardiomyocytes at heart failure associated with chronic stress. The results of immunohystochemical analysis of mice hearts with the model human-like pathology demonstrate heterogeneity in chaperone levels. A considerable increase in Hsp60 staining was observed only in some cardiomyocytes, possibly in those with activated antistress mechanisms of cell defense against chronic stress. |
| doi_str_mv | 10.7124/bc.0007A6 |
| format | Article |
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M. ; Rozhko, O. T. ; Bobyk, V. I. ; Kroupska, I. V. ; Riabenko, D. V. ; Khozhaenko, Yu. S. ; Gurtovyy, V. A. ; Usenko, V. S. ; Sidorik, L. L.</creator><creatorcontrib>Kapustian, L. M. ; Rozhko, O. T. ; Bobyk, V. I. ; Kroupska, I. V. ; Riabenko, D. V. ; Khozhaenko, Yu. S. ; Gurtovyy, V. A. ; Usenko, V. S. ; Sidorik, L. L.</creatorcontrib><description>The changes of Hsp60 content in heart tissue at dilated cardiomyopathy (DCM) were investigated. An increase in Hsp60 level was observed in human hearts affected by DCM as well as in the hearts of mice with disease model similar to human DCM. We observed the increase in Hsp60 level in mitochondria and decrease in cytoplasmic fraction, which could be one of the reasons for apoptotic responce in cardiomyocytes at heart failure associated with chronic stress. The results of immunohystochemical analysis of mice hearts with the model human-like pathology demonstrate heterogeneity in chaperone levels. A considerable increase in Hsp60 staining was observed only in some cardiomyocytes, possibly in those with activated antistress mechanisms of cell defense against chronic stress.</description><identifier>ISSN: 0233-7657</identifier><identifier>EISSN: 1993-6842</identifier><identifier>DOI: 10.7124/bc.0007A6</identifier><language>eng</language><publisher>Kiev: Natsional'na Akademiya Nauk Ukrainy - National Academy of Sciences of Ukraine</publisher><subject>Apoptosis ; Cardiomyocytes ; Cardiomyopathy ; Congestive heart failure ; Dilated cardiomyopathy ; Hsp60 protein ; Mitochondria</subject><ispartof>Biopolimery i kletka, 2008-05, Vol.24 (3), p.238-245</ispartof><rights>2008. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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A considerable increase in Hsp60 staining was observed only in some cardiomyocytes, possibly in those with activated antistress mechanisms of cell defense against chronic stress.</description><subject>Apoptosis</subject><subject>Cardiomyocytes</subject><subject>Cardiomyopathy</subject><subject>Congestive heart failure</subject><subject>Dilated cardiomyopathy</subject><subject>Hsp60 protein</subject><subject>Mitochondria</subject><issn>0233-7657</issn><issn>1993-6842</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNotkL1OwzAYRS0EEqUw8AaWmBhS_Bc7HqsKWqRKLDAi64vtkFRpHGxn6NuTqkx3Obr36iD0SMlKUSZearsihKi1vEILqjUvZCXYNVoQxnmhZKlu0V1KB0KkqBhboO9NC8OPT7gbcG49tmHIfsg4NPgYem-nHiK2LYw-hsHjXRolObOth5hx7lKaPIaMXddD9g5biK4Lx1MYIbene3TTQJ_8w38u0dfb6-dmV-w_tu-b9b6wlCs5_5LaEm4rooSG0iklOVWUlyW42ko7PwWtKi1U46gl4BomgFJdq5I7JhRfoqdL7xjD7-RTNocwxWGeNIyTuYlXJZmp5wtlY0gp-saMsTtCPBlKzNmeqa252ON_Hpxg0A</recordid><startdate>20080520</startdate><enddate>20080520</enddate><creator>Kapustian, L. 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L.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Biopolimery i kletka</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kapustian, L. M.</au><au>Rozhko, O. T.</au><au>Bobyk, V. I.</au><au>Kroupska, I. V.</au><au>Riabenko, D. V.</au><au>Khozhaenko, Yu. S.</au><au>Gurtovyy, V. A.</au><au>Usenko, V. S.</au><au>Sidorik, L. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in the content of molecular chaperone Hsp60 in heart tissue at dilated cardiomyopathy</atitle><jtitle>Biopolimery i kletka</jtitle><date>2008-05-20</date><risdate>2008</risdate><volume>24</volume><issue>3</issue><spage>238</spage><epage>245</epage><pages>238-245</pages><issn>0233-7657</issn><eissn>1993-6842</eissn><abstract>The changes of Hsp60 content in heart tissue at dilated cardiomyopathy (DCM) were investigated. 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| issn | 0233-7657 1993-6842 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Apoptosis Cardiomyocytes Cardiomyopathy Congestive heart failure Dilated cardiomyopathy Hsp60 protein Mitochondria |
| title | Changes in the content of molecular chaperone Hsp60 in heart tissue at dilated cardiomyopathy |
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