Vitamin B3 confers resistance to sulfa drugs in Saccharomyces cerevisiae
Abstract Sulfa drugs are ubiquitous antibiotics used to treat bacterial infections and diseases caused by eukaryotes, such as Pneumocystis carinii, the leading cause of pneumonia (PCP) in HIV patients. A daily regimen of sulfonamides and multivitamins including vitamin B3 is also recommended for per...
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| Veröffentlicht in: | FEMS microbiology letters 2005-10, Vol.251 (1), p.137-141 |
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| container_title | FEMS microbiology letters |
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| creator | Kornfeld, Olga Nichols, Brian P. |
| description | Abstract
Sulfa drugs are ubiquitous antibiotics used to treat bacterial infections and diseases caused by eukaryotes, such as Pneumocystis carinii, the leading cause of pneumonia (PCP) in HIV patients. A daily regimen of sulfonamides and multivitamins including vitamin B3 is also recommended for persons with HIV. We show that exogenous vitamin B3 (nicotinate) confers resistance to sulfa drugs in Saccharomyces cerevisiae, a model for P. carinii. We propose a model of metabolic rerouting in which increased nicotinate leads to increased intracellular concentration of p-aminobenzoate, thus leading to sulfonamide resistance. |
| doi_str_mv | 10.1016/j.femsle.2005.07.037 |
| format | Article |
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Sulfa drugs are ubiquitous antibiotics used to treat bacterial infections and diseases caused by eukaryotes, such as Pneumocystis carinii, the leading cause of pneumonia (PCP) in HIV patients. A daily regimen of sulfonamides and multivitamins including vitamin B3 is also recommended for persons with HIV. We show that exogenous vitamin B3 (nicotinate) confers resistance to sulfa drugs in Saccharomyces cerevisiae, a model for P. carinii. We propose a model of metabolic rerouting in which increased nicotinate leads to increased intracellular concentration of p-aminobenzoate, thus leading to sulfonamide resistance.</description><identifier>ISSN: 0378-1097</identifier><identifier>EISSN: 1574-6968</identifier><identifier>DOI: 10.1016/j.femsle.2005.07.037</identifier><identifier>PMID: 16112818</identifier><identifier>CODEN: FMLED7</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>4-Aminobenzoic Acid - metabolism ; Action of physical and chemical agents on bacteria ; Antibiotics ; Antifungal Agents - pharmacology ; Bacterial diseases ; Bacteriology ; Biological and medical sciences ; Drug Interactions ; Drug resistance ; Drug Resistance, Fungal ; Eukaryotes ; Folate ; Fundamental and applied biological sciences. Psychology ; HIV ; Human immunodeficiency virus ; Microbiology ; Niacinamide - metabolism ; Niacinamide - pharmacology ; Nicotinate ; Nicotinic acid ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - drug effects ; Saccharomyces cerevisiae - metabolism ; Sulfamethoxazole ; Sulfamethoxazole - pharmacology ; Sulfanilamides - pharmacology ; Sulfathiazole ; Sulfathiazoles - pharmacology ; Sulfonamide resistance ; Sulfonamides ; Yeast</subject><ispartof>FEMS microbiology letters, 2005-10, Vol.251 (1), p.137-141</ispartof><rights>2005 Federation of European Microbiological Societies 2005</rights><rights>2005 INIST-CNRS</rights><rights>2005 Federation of European Microbiological Societies</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3227-61075938a073b9eb27860bb2f70c95417c2043ab835005ccf964bf6add02d7d33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.femsle.2005.07.037$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.femsle.2005.07.037$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17101696$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16112818$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kornfeld, Olga</creatorcontrib><creatorcontrib>Nichols, Brian P.</creatorcontrib><title>Vitamin B3 confers resistance to sulfa drugs in Saccharomyces cerevisiae</title><title>FEMS microbiology letters</title><addtitle>FEMS Microbiol Lett</addtitle><description>Abstract
Sulfa drugs are ubiquitous antibiotics used to treat bacterial infections and diseases caused by eukaryotes, such as Pneumocystis carinii, the leading cause of pneumonia (PCP) in HIV patients. A daily regimen of sulfonamides and multivitamins including vitamin B3 is also recommended for persons with HIV. We show that exogenous vitamin B3 (nicotinate) confers resistance to sulfa drugs in Saccharomyces cerevisiae, a model for P. carinii. We propose a model of metabolic rerouting in which increased nicotinate leads to increased intracellular concentration of p-aminobenzoate, thus leading to sulfonamide resistance.</description><subject>4-Aminobenzoic Acid - metabolism</subject><subject>Action of physical and chemical agents on bacteria</subject><subject>Antibiotics</subject><subject>Antifungal Agents - pharmacology</subject><subject>Bacterial diseases</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Drug Interactions</subject><subject>Drug resistance</subject><subject>Drug Resistance, Fungal</subject><subject>Eukaryotes</subject><subject>Folate</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Microbiology</subject><subject>Niacinamide - metabolism</subject><subject>Niacinamide - pharmacology</subject><subject>Nicotinate</subject><subject>Nicotinic acid</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - drug effects</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Sulfamethoxazole</subject><subject>Sulfamethoxazole - pharmacology</subject><subject>Sulfanilamides - pharmacology</subject><subject>Sulfathiazole</subject><subject>Sulfathiazoles - pharmacology</subject><subject>Sulfonamide resistance</subject><subject>Sulfonamides</subject><subject>Yeast</subject><issn>0378-1097</issn><issn>1574-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkctOwzAQRS0EoqXwBwhFQiyTju3EdpZQUYpUxILH1nIcBxLlUewE1L_HVYq6ZTXSzLkzuncQusQQYcBsXkWFaVxtIgKQRMAjoPwITXHC45ClTByjqe-IEEPKJ-jMuQoAYgLsFE0ww5gILKZo9V72qinb4I4GumsLY11gjStdr1ptgr4L3FAXKsjt8OECz70orT-V7ZqtNi7Qxprv0pXKnKOTQtXOXOzrDL0t718Xq3D9_PC4uF2HmhLCQ4aBJykVCjjNUpMRLhhkGSk46DSJMdcEYqoyQRNvS-siZXFWMJXnQHKeUzpD1-Peje2-BuN6WXWDbf1JSSiwJCEpI5662lND1phcbmzZKLuVf8Y9cLMHlNOqLqy3W7oDx3cZp8xzYuR-ytpsD3OQO0BWcnyC3D1BApc-crl8WmPKvXQ-Srth8y8h_QUP2YiF</recordid><startdate>200510</startdate><enddate>200510</enddate><creator>Kornfeld, Olga</creator><creator>Nichols, Brian P.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope></search><sort><creationdate>200510</creationdate><title>Vitamin B3 confers resistance to sulfa drugs in Saccharomyces cerevisiae</title><author>Kornfeld, Olga ; Nichols, Brian P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3227-61075938a073b9eb27860bb2f70c95417c2043ab835005ccf964bf6add02d7d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>4-Aminobenzoic Acid - metabolism</topic><topic>Action of physical and chemical agents on bacteria</topic><topic>Antibiotics</topic><topic>Antifungal Agents - pharmacology</topic><topic>Bacterial diseases</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Drug Interactions</topic><topic>Drug resistance</topic><topic>Drug Resistance, Fungal</topic><topic>Eukaryotes</topic><topic>Folate</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Microbiology</topic><topic>Niacinamide - metabolism</topic><topic>Niacinamide - pharmacology</topic><topic>Nicotinate</topic><topic>Nicotinic acid</topic><topic>Saccharomyces cerevisiae</topic><topic>Saccharomyces cerevisiae - drug effects</topic><topic>Saccharomyces cerevisiae - metabolism</topic><topic>Sulfamethoxazole</topic><topic>Sulfamethoxazole - pharmacology</topic><topic>Sulfanilamides - pharmacology</topic><topic>Sulfathiazole</topic><topic>Sulfathiazoles - pharmacology</topic><topic>Sulfonamide resistance</topic><topic>Sulfonamides</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kornfeld, Olga</creatorcontrib><creatorcontrib>Nichols, Brian P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><jtitle>FEMS microbiology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kornfeld, Olga</au><au>Nichols, Brian P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin B3 confers resistance to sulfa drugs in Saccharomyces cerevisiae</atitle><jtitle>FEMS microbiology letters</jtitle><addtitle>FEMS Microbiol Lett</addtitle><date>2005-10</date><risdate>2005</risdate><volume>251</volume><issue>1</issue><spage>137</spage><epage>141</epage><pages>137-141</pages><issn>0378-1097</issn><eissn>1574-6968</eissn><coden>FMLED7</coden><abstract>Abstract
Sulfa drugs are ubiquitous antibiotics used to treat bacterial infections and diseases caused by eukaryotes, such as Pneumocystis carinii, the leading cause of pneumonia (PCP) in HIV patients. A daily regimen of sulfonamides and multivitamins including vitamin B3 is also recommended for persons with HIV. We show that exogenous vitamin B3 (nicotinate) confers resistance to sulfa drugs in Saccharomyces cerevisiae, a model for P. carinii. We propose a model of metabolic rerouting in which increased nicotinate leads to increased intracellular concentration of p-aminobenzoate, thus leading to sulfonamide resistance.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16112818</pmid><doi>10.1016/j.femsle.2005.07.037</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | FEMS microbiology letters, 2005-10, Vol.251 (1), p.137-141 |
| issn | 0378-1097 1574-6968 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | 4-Aminobenzoic Acid - metabolism Action of physical and chemical agents on bacteria Antibiotics Antifungal Agents - pharmacology Bacterial diseases Bacteriology Biological and medical sciences Drug Interactions Drug resistance Drug Resistance, Fungal Eukaryotes Folate Fundamental and applied biological sciences. Psychology HIV Human immunodeficiency virus Microbiology Niacinamide - metabolism Niacinamide - pharmacology Nicotinate Nicotinic acid Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - metabolism Sulfamethoxazole Sulfamethoxazole - pharmacology Sulfanilamides - pharmacology Sulfathiazole Sulfathiazoles - pharmacology Sulfonamide resistance Sulfonamides Yeast |
| title | Vitamin B3 confers resistance to sulfa drugs in Saccharomyces cerevisiae |
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