Evaluation of Antiinflammatory Activity of 4'-О-Methylhonokiol Derivatives in a Neuroinflammation Model
The synthesis of two derivatives of lignan 4'- O -methylhonokiol ( MH ), i.e., 4'-methoxy-5-propyl-1,1'-biphenyl-2-ol ( III ) and 4'-(2-fluoroethoxy)-2-hydroxy-5-propyl-1,1'-biphenyl ( VI ) has been described. Derivative ( VI ) demonstrates the highest anti-inflammatory acti...
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| Veröffentlicht in: | Russian journal of bioorganic chemistry 2019-09, Vol.45 (5), p.425-429 |
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| container_title | Russian journal of bioorganic chemistry |
| container_volume | 45 |
| creator | Sivak, K. V. Stosman, K. I. Muzhikyan, A. A. Alexandrov, A. G. Viktorov, N. B. Vaulina, D. D. Gomzina, N. A. |
| description | The synthesis of two derivatives of lignan 4'-
O
-methylhonokiol (
MH
), i.e., 4'-methoxy-5-propyl-1,1'-biphenyl-2-ol (
III
) and 4'-(2-fluoroethoxy)-2-hydroxy-5-propyl-1,1'-biphenyl (
VI
) has been described. Derivative (
VI
) demonstrates the highest anti-inflammatory activity in the lipopolysaccharide-induced (LPS-induced) neuroinflammation mouse model. Its effect on the morphological changes in the brain is comparable to that of celecoxib, a well-known nonsteroid anti-inflammatory drug and a selective inhibitor of cyclooxygenase-2 (COX 2). |
| doi_str_mv | 10.1134/S1068162019040113 |
| format | Article |
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O
-methylhonokiol (
MH
), i.e., 4'-methoxy-5-propyl-1,1'-biphenyl-2-ol (
III
) and 4'-(2-fluoroethoxy)-2-hydroxy-5-propyl-1,1'-biphenyl (
VI
) has been described. Derivative (
VI
) demonstrates the highest anti-inflammatory activity in the lipopolysaccharide-induced (LPS-induced) neuroinflammation mouse model. Its effect on the morphological changes in the brain is comparable to that of celecoxib, a well-known nonsteroid anti-inflammatory drug and a selective inhibitor of cyclooxygenase-2 (COX 2).</description><identifier>ISSN: 1068-1620</identifier><identifier>EISSN: 1608-330X</identifier><identifier>DOI: 10.1134/S1068162019040113</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; Derivatives ; Letter to Editor ; Life Sciences ; Organic Chemistry</subject><ispartof>Russian journal of bioorganic chemistry, 2019-09, Vol.45 (5), p.425-429</ispartof><rights>Pleiades Publishing, Ltd. 2019</rights><rights>Copyright Springer Nature B.V. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2313-26203198fe820f3b240b08527f7d9f1fa96ac4d49682ba966b994b3318ca5333</citedby><cites>FETCH-LOGICAL-c2313-26203198fe820f3b240b08527f7d9f1fa96ac4d49682ba966b994b3318ca5333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1068162019040113$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1068162019040113$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Sivak, K. V.</creatorcontrib><creatorcontrib>Stosman, K. I.</creatorcontrib><creatorcontrib>Muzhikyan, A. A.</creatorcontrib><creatorcontrib>Alexandrov, A. G.</creatorcontrib><creatorcontrib>Viktorov, N. B.</creatorcontrib><creatorcontrib>Vaulina, D. D.</creatorcontrib><creatorcontrib>Gomzina, N. A.</creatorcontrib><title>Evaluation of Antiinflammatory Activity of 4'-О-Methylhonokiol Derivatives in a Neuroinflammation Model</title><title>Russian journal of bioorganic chemistry</title><addtitle>Russ J Bioorg Chem</addtitle><description>The synthesis of two derivatives of lignan 4'-
O
-methylhonokiol (
MH
), i.e., 4'-methoxy-5-propyl-1,1'-biphenyl-2-ol (
III
) and 4'-(2-fluoroethoxy)-2-hydroxy-5-propyl-1,1'-biphenyl (
VI
) has been described. Derivative (
VI
) demonstrates the highest anti-inflammatory activity in the lipopolysaccharide-induced (LPS-induced) neuroinflammation mouse model. Its effect on the morphological changes in the brain is comparable to that of celecoxib, a well-known nonsteroid anti-inflammatory drug and a selective inhibitor of cyclooxygenase-2 (COX 2).</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Derivatives</subject><subject>Letter to Editor</subject><subject>Life Sciences</subject><subject>Organic Chemistry</subject><issn>1068-1620</issn><issn>1608-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1ULtOwzAUtRBIlMAHsEViYApcP5I6Y1XKQ2phoANb5KQ2dUnjYjuR8jN8E5-EoyIYENN9nNfVRegcwxXGlF0_Y8g4zgjgHBiE1QEa4Qx4Qim8HIY-wMmAH6MT5zYAGCDlI7SedaJuhdemiY2KJ43XulG12G6FN7aPJ5XXnfb9ALLL5PMjWUi_7uu1acybNnV8I63ugr6TLtZNLOJH2Vrz4zH4LsxK1qfoSInaybPvGqHl7Ww5vU_mT3cP08k8qQjFNCHhRIpzriQnoGhJGJTAUzJW41WusBJ5Jiq2YnnGSRmGrMxzVlKKeSVSSmmELva2O2veW-l8sTGtbUJiQShkKWU8xEQI71mVNc5ZqYqd1Vth-wJDMfyz-PPPoCF7jQvc5lXaX-f_RV9ONXdH</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Sivak, K. V.</creator><creator>Stosman, K. I.</creator><creator>Muzhikyan, A. A.</creator><creator>Alexandrov, A. G.</creator><creator>Viktorov, N. B.</creator><creator>Vaulina, D. D.</creator><creator>Gomzina, N. A.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20190901</creationdate><title>Evaluation of Antiinflammatory Activity of 4'-О-Methylhonokiol Derivatives in a Neuroinflammation Model</title><author>Sivak, K. V. ; Stosman, K. I. ; Muzhikyan, A. A. ; Alexandrov, A. G. ; Viktorov, N. B. ; Vaulina, D. D. ; Gomzina, N. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2313-26203198fe820f3b240b08527f7d9f1fa96ac4d49682ba966b994b3318ca5333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>Derivatives</topic><topic>Letter to Editor</topic><topic>Life Sciences</topic><topic>Organic Chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sivak, K. V.</creatorcontrib><creatorcontrib>Stosman, K. I.</creatorcontrib><creatorcontrib>Muzhikyan, A. A.</creatorcontrib><creatorcontrib>Alexandrov, A. G.</creatorcontrib><creatorcontrib>Viktorov, N. B.</creatorcontrib><creatorcontrib>Vaulina, D. D.</creatorcontrib><creatorcontrib>Gomzina, N. A.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of bioorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sivak, K. V.</au><au>Stosman, K. I.</au><au>Muzhikyan, A. A.</au><au>Alexandrov, A. G.</au><au>Viktorov, N. B.</au><au>Vaulina, D. D.</au><au>Gomzina, N. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Antiinflammatory Activity of 4'-О-Methylhonokiol Derivatives in a Neuroinflammation Model</atitle><jtitle>Russian journal of bioorganic chemistry</jtitle><stitle>Russ J Bioorg Chem</stitle><date>2019-09-01</date><risdate>2019</risdate><volume>45</volume><issue>5</issue><spage>425</spage><epage>429</epage><pages>425-429</pages><issn>1068-1620</issn><eissn>1608-330X</eissn><abstract>The synthesis of two derivatives of lignan 4'-
O
-methylhonokiol (
MH
), i.e., 4'-methoxy-5-propyl-1,1'-biphenyl-2-ol (
III
) and 4'-(2-fluoroethoxy)-2-hydroxy-5-propyl-1,1'-biphenyl (
VI
) has been described. Derivative (
VI
) demonstrates the highest anti-inflammatory activity in the lipopolysaccharide-induced (LPS-induced) neuroinflammation mouse model. Its effect on the morphological changes in the brain is comparable to that of celecoxib, a well-known nonsteroid anti-inflammatory drug and a selective inhibitor of cyclooxygenase-2 (COX 2).</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1068162019040113</doi><tpages>5</tpages></addata></record> |
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| subjects | Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Derivatives Letter to Editor Life Sciences Organic Chemistry |
| title | Evaluation of Antiinflammatory Activity of 4'-О-Methylhonokiol Derivatives in a Neuroinflammation Model |
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