Exosome-mediated therapeutic delivery: A new horizon for human neurodegenerative disorders’ treatment (with a focus on siRNA delivery improvement)
•CNS degenerative disorders are one of the leading causes of death worldwide.•siRNA application developed a new perspective to treat gene related diseases.•One of the newly developed approaches to improve siRNA delivery is exosome.•Exosome improves drug delivery through blood-brain barrier in CNS di...
Gespeichert in:
| Veröffentlicht in: | Process biochemistry (1991) 2019-10, Vol.85, p.164-174 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 174 |
|---|---|
| container_issue | |
| container_start_page | 164 |
| container_title | Process biochemistry (1991) |
| container_volume | 85 |
| creator | Seyfizadeh, Nayer Seyfizadeh, Narges Borzouisileh, Sajad Elahimanesh, Farideh Hosseini, Vahid Nouri, Mohammad |
| description | •CNS degenerative disorders are one of the leading causes of death worldwide.•siRNA application developed a new perspective to treat gene related diseases.•One of the newly developed approaches to improve siRNA delivery is exosome.•Exosome improves drug delivery through blood-brain barrier in CNS disorders
Neurodegenerative disorders are one of the leading causes of death and disability worldwide, which also poses major burden on health care systems. siRNA opens a new perspective to treat diseases pertaining to gene functions by silencing its targeted mechanisms. Exosome-mediated siRNA is a newly developed unique approach in order to improve the efficiency of siRNA delivery system. This method is potentially a convenient scheme for CNS disorders, because of its therapeutic based delivery mechanistic approach across the blood-brain barrier (BBB).
Exosomes are extracellular nanostructures that could carry a variety of cargoes and performs many different functions based on their origin. Exosomes. In this review, we mainly focus on the third application and discuss exosome biogenesis and its therapeutic applications in neurodegenerative disorders. We summarize the latest studies on how exosome improves small RNA therapy and give an overview of exosome cargo loading techniques, its source cell selection, and efficient delivery routes. |
| doi_str_mv | 10.1016/j.procbio.2019.06.025 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2306477252</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1359511319304738</els_id><sourcerecordid>2306477252</sourcerecordid><originalsourceid>FETCH-LOGICAL-c374t-7bf6d08e29fbaa3215b135239dbd16dcecce469039079af6f8566e1530d71bd13</originalsourceid><addsrcrecordid>eNqFUctKAzEUDaKgVj9BCLjRxYzJpJPpuJFS6gOKgug6ZJI7NqUzqUmmta78CDf-nl9iSsWtq3u5nAfnHoROKEkpofxili6cVZWxaUZomRKekizfQQd0ULCEZeVgN-4sL5OcUraPDr2fEcIopeQAfY7frLcNJA1oIwNoHKbg5AK6YBTWMDdLcOtLPMQtrPDUOvNuW1xbh6ddI9t47ZzV8AJtZIUIxtp46zQ4__3xhYMDGRpoAz5bmTDFMlJV53HU8ObxfvjngE0TQyxhgz0_Qnu1nHs4_p099Hw9fhrdJpOHm7vRcJIoVvRDUlQ112QAWVlXUrKM5lWMmbFSV5pyrUAp6POSsJIUpax5Pcg5B5ozogsaIayHTre60fq1Ax_EzHaujZYiY4T3iyKLcj2Ub1HKWe8d1GLhTCPdWlAiNgWImfgtQGwKEISLWEDkXW15ECMsDTjhlYFWxUc7UEFoa_5R-AFmqpYI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2306477252</pqid></control><display><type>article</type><title>Exosome-mediated therapeutic delivery: A new horizon for human neurodegenerative disorders’ treatment (with a focus on siRNA delivery improvement)</title><source>Elsevier ScienceDirect Journals</source><creator>Seyfizadeh, Nayer ; Seyfizadeh, Narges ; Borzouisileh, Sajad ; Elahimanesh, Farideh ; Hosseini, Vahid ; Nouri, Mohammad</creator><creatorcontrib>Seyfizadeh, Nayer ; Seyfizadeh, Narges ; Borzouisileh, Sajad ; Elahimanesh, Farideh ; Hosseini, Vahid ; Nouri, Mohammad</creatorcontrib><description>•CNS degenerative disorders are one of the leading causes of death worldwide.•siRNA application developed a new perspective to treat gene related diseases.•One of the newly developed approaches to improve siRNA delivery is exosome.•Exosome improves drug delivery through blood-brain barrier in CNS disorders
Neurodegenerative disorders are one of the leading causes of death and disability worldwide, which also poses major burden on health care systems. siRNA opens a new perspective to treat diseases pertaining to gene functions by silencing its targeted mechanisms. Exosome-mediated siRNA is a newly developed unique approach in order to improve the efficiency of siRNA delivery system. This method is potentially a convenient scheme for CNS disorders, because of its therapeutic based delivery mechanistic approach across the blood-brain barrier (BBB).
Exosomes are extracellular nanostructures that could carry a variety of cargoes and performs many different functions based on their origin. Exosomes. In this review, we mainly focus on the third application and discuss exosome biogenesis and its therapeutic applications in neurodegenerative disorders. We summarize the latest studies on how exosome improves small RNA therapy and give an overview of exosome cargo loading techniques, its source cell selection, and efficient delivery routes.</description><identifier>ISSN: 1359-5113</identifier><identifier>EISSN: 1873-3298</identifier><identifier>DOI: 10.1016/j.procbio.2019.06.025</identifier><language>eng</language><publisher>Barking: Elsevier Ltd</publisher><subject>Blood-brain barrier ; CNS diseases ; Disorders ; Exosome ; Exosomes ; Gene therapy ; Neurodegenerative disease ; Neurodegenerative diseases ; Reviews ; siRNA ; Therapeutic applications</subject><ispartof>Process biochemistry (1991), 2019-10, Vol.85, p.164-174</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright Elsevier BV Oct 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-7bf6d08e29fbaa3215b135239dbd16dcecce469039079af6f8566e1530d71bd13</citedby><cites>FETCH-LOGICAL-c374t-7bf6d08e29fbaa3215b135239dbd16dcecce469039079af6f8566e1530d71bd13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.procbio.2019.06.025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids></links><search><creatorcontrib>Seyfizadeh, Nayer</creatorcontrib><creatorcontrib>Seyfizadeh, Narges</creatorcontrib><creatorcontrib>Borzouisileh, Sajad</creatorcontrib><creatorcontrib>Elahimanesh, Farideh</creatorcontrib><creatorcontrib>Hosseini, Vahid</creatorcontrib><creatorcontrib>Nouri, Mohammad</creatorcontrib><title>Exosome-mediated therapeutic delivery: A new horizon for human neurodegenerative disorders’ treatment (with a focus on siRNA delivery improvement)</title><title>Process biochemistry (1991)</title><description>•CNS degenerative disorders are one of the leading causes of death worldwide.•siRNA application developed a new perspective to treat gene related diseases.•One of the newly developed approaches to improve siRNA delivery is exosome.•Exosome improves drug delivery through blood-brain barrier in CNS disorders
Neurodegenerative disorders are one of the leading causes of death and disability worldwide, which also poses major burden on health care systems. siRNA opens a new perspective to treat diseases pertaining to gene functions by silencing its targeted mechanisms. Exosome-mediated siRNA is a newly developed unique approach in order to improve the efficiency of siRNA delivery system. This method is potentially a convenient scheme for CNS disorders, because of its therapeutic based delivery mechanistic approach across the blood-brain barrier (BBB).
Exosomes are extracellular nanostructures that could carry a variety of cargoes and performs many different functions based on their origin. Exosomes. In this review, we mainly focus on the third application and discuss exosome biogenesis and its therapeutic applications in neurodegenerative disorders. We summarize the latest studies on how exosome improves small RNA therapy and give an overview of exosome cargo loading techniques, its source cell selection, and efficient delivery routes.</description><subject>Blood-brain barrier</subject><subject>CNS diseases</subject><subject>Disorders</subject><subject>Exosome</subject><subject>Exosomes</subject><subject>Gene therapy</subject><subject>Neurodegenerative disease</subject><subject>Neurodegenerative diseases</subject><subject>Reviews</subject><subject>siRNA</subject><subject>Therapeutic applications</subject><issn>1359-5113</issn><issn>1873-3298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFUctKAzEUDaKgVj9BCLjRxYzJpJPpuJFS6gOKgug6ZJI7NqUzqUmmta78CDf-nl9iSsWtq3u5nAfnHoROKEkpofxili6cVZWxaUZomRKekizfQQd0ULCEZeVgN-4sL5OcUraPDr2fEcIopeQAfY7frLcNJA1oIwNoHKbg5AK6YBTWMDdLcOtLPMQtrPDUOvNuW1xbh6ddI9t47ZzV8AJtZIUIxtp46zQ4__3xhYMDGRpoAz5bmTDFMlJV53HU8ObxfvjngE0TQyxhgz0_Qnu1nHs4_p099Hw9fhrdJpOHm7vRcJIoVvRDUlQ112QAWVlXUrKM5lWMmbFSV5pyrUAp6POSsJIUpax5Pcg5B5ozogsaIayHTre60fq1Ax_EzHaujZYiY4T3iyKLcj2Ub1HKWe8d1GLhTCPdWlAiNgWImfgtQGwKEISLWEDkXW15ECMsDTjhlYFWxUc7UEFoa_5R-AFmqpYI</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Seyfizadeh, Nayer</creator><creator>Seyfizadeh, Narges</creator><creator>Borzouisileh, Sajad</creator><creator>Elahimanesh, Farideh</creator><creator>Hosseini, Vahid</creator><creator>Nouri, Mohammad</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20191001</creationdate><title>Exosome-mediated therapeutic delivery: A new horizon for human neurodegenerative disorders’ treatment (with a focus on siRNA delivery improvement)</title><author>Seyfizadeh, Nayer ; Seyfizadeh, Narges ; Borzouisileh, Sajad ; Elahimanesh, Farideh ; Hosseini, Vahid ; Nouri, Mohammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-7bf6d08e29fbaa3215b135239dbd16dcecce469039079af6f8566e1530d71bd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Blood-brain barrier</topic><topic>CNS diseases</topic><topic>Disorders</topic><topic>Exosome</topic><topic>Exosomes</topic><topic>Gene therapy</topic><topic>Neurodegenerative disease</topic><topic>Neurodegenerative diseases</topic><topic>Reviews</topic><topic>siRNA</topic><topic>Therapeutic applications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seyfizadeh, Nayer</creatorcontrib><creatorcontrib>Seyfizadeh, Narges</creatorcontrib><creatorcontrib>Borzouisileh, Sajad</creatorcontrib><creatorcontrib>Elahimanesh, Farideh</creatorcontrib><creatorcontrib>Hosseini, Vahid</creatorcontrib><creatorcontrib>Nouri, Mohammad</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Process biochemistry (1991)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seyfizadeh, Nayer</au><au>Seyfizadeh, Narges</au><au>Borzouisileh, Sajad</au><au>Elahimanesh, Farideh</au><au>Hosseini, Vahid</au><au>Nouri, Mohammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exosome-mediated therapeutic delivery: A new horizon for human neurodegenerative disorders’ treatment (with a focus on siRNA delivery improvement)</atitle><jtitle>Process biochemistry (1991)</jtitle><date>2019-10-01</date><risdate>2019</risdate><volume>85</volume><spage>164</spage><epage>174</epage><pages>164-174</pages><issn>1359-5113</issn><eissn>1873-3298</eissn><abstract>•CNS degenerative disorders are one of the leading causes of death worldwide.•siRNA application developed a new perspective to treat gene related diseases.•One of the newly developed approaches to improve siRNA delivery is exosome.•Exosome improves drug delivery through blood-brain barrier in CNS disorders
Neurodegenerative disorders are one of the leading causes of death and disability worldwide, which also poses major burden on health care systems. siRNA opens a new perspective to treat diseases pertaining to gene functions by silencing its targeted mechanisms. Exosome-mediated siRNA is a newly developed unique approach in order to improve the efficiency of siRNA delivery system. This method is potentially a convenient scheme for CNS disorders, because of its therapeutic based delivery mechanistic approach across the blood-brain barrier (BBB).
Exosomes are extracellular nanostructures that could carry a variety of cargoes and performs many different functions based on their origin. Exosomes. In this review, we mainly focus on the third application and discuss exosome biogenesis and its therapeutic applications in neurodegenerative disorders. We summarize the latest studies on how exosome improves small RNA therapy and give an overview of exosome cargo loading techniques, its source cell selection, and efficient delivery routes.</abstract><cop>Barking</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.procbio.2019.06.025</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-5113 |
| ispartof | Process biochemistry (1991), 2019-10, Vol.85, p.164-174 |
| issn | 1359-5113 1873-3298 |
| language | eng |
| recordid | cdi_proquest_journals_2306477252 |
| source | Elsevier ScienceDirect Journals |
| subjects | Blood-brain barrier CNS diseases Disorders Exosome Exosomes Gene therapy Neurodegenerative disease Neurodegenerative diseases Reviews siRNA Therapeutic applications |
| title | Exosome-mediated therapeutic delivery: A new horizon for human neurodegenerative disorders’ treatment (with a focus on siRNA delivery improvement) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T21%3A47%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Exosome-mediated%20therapeutic%20delivery:%20A%20new%20horizon%20for%20human%20neurodegenerative%20disorders%E2%80%99%20treatment%20(with%20a%20focus%20on%20siRNA%20delivery%20improvement)&rft.jtitle=Process%20biochemistry%20(1991)&rft.au=Seyfizadeh,%20Nayer&rft.date=2019-10-01&rft.volume=85&rft.spage=164&rft.epage=174&rft.pages=164-174&rft.issn=1359-5113&rft.eissn=1873-3298&rft_id=info:doi/10.1016/j.procbio.2019.06.025&rft_dat=%3Cproquest_cross%3E2306477252%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2306477252&rft_id=info:pmid/&rft_els_id=S1359511319304738&rfr_iscdi=true |