Hemagglutinin gene shuffling among Clostridium botulinum serotypes C and D yields distinct sugar recognition of the botulinum toxin complex

Clostridium botulinum strains produce a large-sized toxin complex (TC) that is composed of botulinum neurotoxin (BoNT), non-toxic non-hemagglutinin and three different hemagglutinins (HA-70, HA-33 and HA-17). HA components enhance toxin delivery across the intestinal cell wall in a sugar chain-depen...

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Veröffentlicht in:	Pathogens and disease 2015-10, Vol.73 (7), p.ftv054
Hauptverfasser:	Miyata, Keita, Suzuki, Tomonori, Hayashi, Shintaro, Miyashita, Shin-Ichiro, Ohyama, Tohru, Niwa, Koichi, Watanabe, Toshihiro, Sagane, Yoshimasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Amino acids Animals Bacteria Botulinum toxin Botulinum toxin type C Botulinum toxin type D Botulinum Toxins - metabolism Cell Line Cell surface Cell walls Clostridium botulinum Clostridium botulinum - genetics DNA Shuffling Epithelial Cells - metabolism Erythrocytes Exo-a-sialidase Hemagglutination Tests Hemagglutinins Hemagglutinins - genetics Hemagglutinins - metabolism Horses Intestine Neurotoxins Oligosaccharides Oligosaccharides - metabolism Protein Binding Rats Recognition Serotypes Substrate Specificity Sugar Toxins
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