Large-scale chromatin remodelling and transcriptional deregulation on der11 following translocation in Mantle Cell Lymphoma

Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma characterized by poor prognosis and survival rate. Its genetic hallmark is the translocation t(11;14) which leads to the overexpression of cyclin D1 (CCND1) gene which becomes juxtaposed to the immunoglobulin heavy chain (IGH) g...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biopolimery i kletka 2019-05, Vol.35 (3), p.210-211
Hauptverfasser:	Germini, D., Bintou Sall, F., Markozashvili, D., Pichugin, A., Camara-Clayette, V., Ribrag, V., Lipinski, M., Vassetzky, Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Chromatin remodeling Conserved sequence Cyclin D1 Enhancers Epigenetics Gene expression Gene loci Genomes Heavy chains Image processing Immunoglobulins Lymphocytes B Lymphoma Mantle cell lymphoma Medical prognosis Non-Hodgkin's lymphoma Nucleoli Nucleolin Phenotypes Polymerase chain reaction Transgenic mice Tumorigenesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!