Probing the chromatin structure of ribosomal DNA using extended chromatin fibers

The chromatin organization of ribosomal genes, which encode essential 25S, 18S and 5.8S ribosomal RNA, remains unresolved to this day in many biological models. Hundreds of rDNA copies exist in the genome in a mostly tandem, head-to-tail arrangement. Nucleoli, the main transcription factories of the...

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