Helicobacter pylori FKBP-type PPIase promotes gastric epithelial cell proliferation and anchorage-independent growth through activation of ERK-mediated mitogenic signaling pathway

Though Helicobacter pylori (H. pylori) has been classified as class I carcinogen, key virulence factor(s) generated by H. pylori that causes gastric cancer remains to be fully determined. Here, we show that deletion of peptidyl-prolyl cis–trans isomerase (PPIase) prevented H. pylori from stimulating...

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Veröffentlicht in:	FEMS microbiology letters 2015-04, Vol.362 (7)
Hauptverfasser:	Zhu, Yanmei, Chen, Moye, Gong, Yuehua, Liu, Ziyang, Li, Aodi, Kang, Dan, Han, Fang, Liu, Jingwei, Liu, Jun, Yuan, Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cancer Carcinogens Cell growth Cell Line Cell Proliferation Clonal deletion Ectopic expression Epithelial cells Epithelial Cells - cytology Epithelial Cells - metabolism Epithelial Cells - microbiology Extracellular signal-regulated kinase Gastric cancer Gastric Mucosa - cytology Gastric Mucosa - metabolism Gastric Mucosa - microbiology Gene Deletion Helicobacter pylori Helicobacter pylori - enzymology Helicobacter pylori - genetics Helicobacter pylori - pathogenicity Humans Kinases MAP Kinase Signaling System MEK inhibitors Microbiology Mitogens Pathogens Peptidylprolyl isomerase Peptidylprolyl Isomerase - genetics Peptidylprolyl Isomerase - metabolism Phosphorylation Receptor, Epidermal Growth Factor - metabolism Signal transduction Signaling Stomach Neoplasms - therapy Tacrolimus-binding protein Virulence Virulence factors
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