Functional mimetic peptide discovery isolated by phage display interacts selectively to fibronectin domain and inhibits gelatinase

Matrix metalloproteinases (MMPs) play critical roles in a multiple number of autoimmunity diseases progression and metastasis of solid tumor. Gelatinases including MMP‐2 and MMP‐9 are extremely overexpressed in multiple pathological processes. MMP‐9 and MMP‐2 breakdown the extracellular matrix compo...

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Veröffentlicht in:	Journal of cellular biochemistry 2019-12, Vol.120 (12), p.19699-19711
Hauptverfasser:	Shoari, Alireza, Rasaee, Mohammad J., Kanavi, Mozhgan R., Daraei, Bahram
Format:	Artikel
Sprache:	eng
Schlagworte:	Assaying Autoimmune diseases Autoimmunity Clinical trials Conserved sequence Degradation Extracellular matrix Fibronectin fibronectin domain Fluorescein Fluorescein isothiocyanate Gelatin gelatin degradation Gelatinase Inhibitors invasion Matrix metalloproteinase Matrix metalloproteinases Metastases MMP‐9 Molecular docking Peptide libraries Peptides Phage display phage display peptide library Phages Proteins Proteolysis Selectivity Solid tumors Tumors
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