Interleukin-8 and Tumor Necrosis Factor-Alpha Are Increased in Minimal Change Disease but Do Not Alter Albumin Permeability
Aims: Minimal change disease (MCD) is the most common primary nephrotic syndrome in children. Some suggested that interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) are involved in the pathogenesis of MCD. This study was done to see changes of plasma and urinary IL-8, TNF-α, and their effects...
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| Veröffentlicht in: | American journal of nephrology 2003-07, Vol.23 (4), p.260-266 |
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| creator | Cho, Min Hyun Lee, Hwan Seok Choe, Byung Ho Kwon, Soon Hak Chung, Ki Young Koo, Ja Hoon Ko, Cheol Woo |
| description | Aims: Minimal change disease (MCD) is the most common primary nephrotic syndrome in children. Some suggested that interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) are involved in the pathogenesis of MCD. This study was done to see changes of plasma and urinary IL-8, TNF-α, and their effects on determination of permeability of glomerular basement membrane (BM) contributed by heparan sulfate proteoglycan (HSPG). Methods: Study patients consisted of 19 biopsy-proven MCD children aged 2–15 years old. Both plasma, urinary IL-8 and TNF-α were measured. Employing the Millicell system, IL-8 and TNF-α were screened for the permeability factors. We examined whether IL-8 and TNF-α regulated BM HSPG gene expression and HS synthesis in the glomerular epithelial cells (GECs). Results: Urinary IL-8 during relapse was significantly increased when compared with that of during remission or controls (13,996 ± 2,811 vs. 2,941 ± 373, 5,331 ± 640 ng/mg·cr) (p < 0.05). Urinary TNF-α during relapse was also significantly increased (364.4 ± 51.2 vs. 155.3 ± 20.8, 36.0 ± 4.5 ng/mg·cr) (p < 0.05). Plasma IL-8 during relapse was significantly increased compared to that during remission(1.19 ± 0.62 vs. 0.51 ± 0.42 ng/ml) (p < 0.05). However, the negative results were obtained in the permeability assay using the Millicell system. No difference was seen in BM HSPG gene expression and HS synthesis in the GECs. Conclusion: Therefore, it seems that both IL-8 and TNF-α may not play a disease-specific role in the pathogenesis of MCD. |
| doi_str_mv | 10.1159/000072065 |
| format | Article |
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Some suggested that interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) are involved in the pathogenesis of MCD. This study was done to see changes of plasma and urinary IL-8, TNF-α, and their effects on determination of permeability of glomerular basement membrane (BM) contributed by heparan sulfate proteoglycan (HSPG). Methods: Study patients consisted of 19 biopsy-proven MCD children aged 2–15 years old. Both plasma, urinary IL-8 and TNF-α were measured. Employing the Millicell system, IL-8 and TNF-α were screened for the permeability factors. We examined whether IL-8 and TNF-α regulated BM HSPG gene expression and HS synthesis in the glomerular epithelial cells (GECs). Results: Urinary IL-8 during relapse was significantly increased when compared with that of during remission or controls (13,996 ± 2,811 vs. 2,941 ± 373, 5,331 ± 640 ng/mg·cr) (p < 0.05). Urinary TNF-α during relapse was also significantly increased (364.4 ± 51.2 vs. 155.3 ± 20.8, 36.0 ± 4.5 ng/mg·cr) (p < 0.05). Plasma IL-8 during relapse was significantly increased compared to that during remission(1.19 ± 0.62 vs. 0.51 ± 0.42 ng/ml) (p < 0.05). However, the negative results were obtained in the permeability assay using the Millicell system. No difference was seen in BM HSPG gene expression and HS synthesis in the GECs. Conclusion: Therefore, it seems that both IL-8 and TNF-α may not play a disease-specific role in the pathogenesis of MCD.</description><identifier>ISSN: 0250-8095</identifier><identifier>EISSN: 1421-9670</identifier><identifier>DOI: 10.1159/000072065</identifier><identifier>PMID: 12840601</identifier><identifier>CODEN: AJNED9</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adolescent ; Albumins - metabolism ; Basement Membrane - physiopathology ; Biological and medical sciences ; Child ; Child, Preschool ; Epithelium - metabolism ; Female ; Glomerulonephritis ; Heparan Sulfate Proteoglycans - metabolism ; Heparitin Sulfate - metabolism ; Humans ; Interleukin-8 - metabolism ; Kidney Glomerulus - metabolism ; Kidney Glomerulus - physiopathology ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Nephrosis, Lipoid - metabolism ; Original Article: Patient-Oriented, Translational Research ; Permeability ; Recurrence ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>American journal of nephrology, 2003-07, Vol.23 (4), p.260-266</ispartof><rights>2003 S. Karger AG, Basel</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2003 S. Karger AG, Basel</rights><rights>Copyright S. Karger AG Jul/Aug 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-f450e739bf9e6c7a06bc8046df460ee85a2730d42b2e2672691638bf5b761403</citedby><cites>FETCH-LOGICAL-c451t-f450e739bf9e6c7a06bc8046df460ee85a2730d42b2e2672691638bf5b761403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15004893$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12840601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cho, Min Hyun</creatorcontrib><creatorcontrib>Lee, Hwan Seok</creatorcontrib><creatorcontrib>Choe, Byung Ho</creatorcontrib><creatorcontrib>Kwon, Soon Hak</creatorcontrib><creatorcontrib>Chung, Ki Young</creatorcontrib><creatorcontrib>Koo, Ja Hoon</creatorcontrib><creatorcontrib>Ko, Cheol Woo</creatorcontrib><title>Interleukin-8 and Tumor Necrosis Factor-Alpha Are Increased in Minimal Change Disease but Do Not Alter Albumin Permeability</title><title>American journal of nephrology</title><addtitle>Am J Nephrol</addtitle><description>Aims: Minimal change disease (MCD) is the most common primary nephrotic syndrome in children. Some suggested that interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) are involved in the pathogenesis of MCD. This study was done to see changes of plasma and urinary IL-8, TNF-α, and their effects on determination of permeability of glomerular basement membrane (BM) contributed by heparan sulfate proteoglycan (HSPG). Methods: Study patients consisted of 19 biopsy-proven MCD children aged 2–15 years old. Both plasma, urinary IL-8 and TNF-α were measured. Employing the Millicell system, IL-8 and TNF-α were screened for the permeability factors. We examined whether IL-8 and TNF-α regulated BM HSPG gene expression and HS synthesis in the glomerular epithelial cells (GECs). Results: Urinary IL-8 during relapse was significantly increased when compared with that of during remission or controls (13,996 ± 2,811 vs. 2,941 ± 373, 5,331 ± 640 ng/mg·cr) (p < 0.05). Urinary TNF-α during relapse was also significantly increased (364.4 ± 51.2 vs. 155.3 ± 20.8, 36.0 ± 4.5 ng/mg·cr) (p < 0.05). Plasma IL-8 during relapse was significantly increased compared to that during remission(1.19 ± 0.62 vs. 0.51 ± 0.42 ng/ml) (p < 0.05). However, the negative results were obtained in the permeability assay using the Millicell system. No difference was seen in BM HSPG gene expression and HS synthesis in the GECs. Conclusion: Therefore, it seems that both IL-8 and TNF-α may not play a disease-specific role in the pathogenesis of MCD.</description><subject>Adolescent</subject><subject>Albumins - metabolism</subject><subject>Basement Membrane - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Epithelium - metabolism</subject><subject>Female</subject><subject>Glomerulonephritis</subject><subject>Heparan Sulfate Proteoglycans - metabolism</subject><subject>Heparitin Sulfate - metabolism</subject><subject>Humans</subject><subject>Interleukin-8 - metabolism</subject><subject>Kidney Glomerulus - metabolism</subject><subject>Kidney Glomerulus - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Nephrosis, Lipoid - metabolism</subject><subject>Original Article: Patient-Oriented, Translational Research</subject><subject>Permeability</subject><subject>Recurrence</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0250-8095</issn><issn>1421-9670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0Utv1DAQAGALUdGlcOCMhKxKIHEIjB0_4mO0pbBVWTjsPXKSSes2cRY7OVT8ebzs0koVUn3wHObTjGaGkDcMPjEmzWdIT3NQ8hlZMMFZZpSG52QBXEJWgJHH5GWMNwCMF6BfkOMUBShgC_J75ScMPc63zmcFtb6lm3kYA11jE8boIj23zTSGrOy315aWAenKNwFtxJY6T7877wbb0-W19VdIz1zcpWg9T_RspOtxomWfGqS_nofkf2IY0Naud9PdK3LU2T7i60M8IZvzL5vlt-zyx9fVsrzMGiHZlHVCAurc1J1B1WgLqm4KEKrthALEQlquc2gFrzlypbkyTOVF3claKyYgPyEf9mW3Yfw1Y5yqwcUG-956HOdY6VzmhVTiScjBgNRCJ3j6CN6Mc_BphornIAqmzQ593KPdHmPArtqGtKpwVzGodmer7s-W7LtDwbkesH2Qhzsl8P4AbGxs3wXrGxcfnITU1uTJvd27WxuuMNyDf21O_5stL9Z_QbVtu_wPeH-xKw</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>Cho, Min Hyun</creator><creator>Lee, Hwan Seok</creator><creator>Choe, Byung Ho</creator><creator>Kwon, Soon Hak</creator><creator>Chung, Ki Young</creator><creator>Koo, Ja Hoon</creator><creator>Ko, Cheol Woo</creator><general>Karger</general><general>S. 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Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Nephrosis, Lipoid - metabolism</topic><topic>Original Article: Patient-Oriented, Translational Research</topic><topic>Permeability</topic><topic>Recurrence</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cho, Min Hyun</creatorcontrib><creatorcontrib>Lee, Hwan Seok</creatorcontrib><creatorcontrib>Choe, Byung Ho</creatorcontrib><creatorcontrib>Kwon, Soon Hak</creatorcontrib><creatorcontrib>Chung, Ki Young</creatorcontrib><creatorcontrib>Koo, Ja Hoon</creatorcontrib><creatorcontrib>Ko, Cheol Woo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>Immunology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cho, Min Hyun</au><au>Lee, Hwan Seok</au><au>Choe, Byung Ho</au><au>Kwon, Soon Hak</au><au>Chung, Ki Young</au><au>Koo, Ja Hoon</au><au>Ko, Cheol Woo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-8 and Tumor Necrosis Factor-Alpha Are Increased in Minimal Change Disease but Do Not Alter Albumin Permeability</atitle><jtitle>American journal of nephrology</jtitle><addtitle>Am J Nephrol</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>23</volume><issue>4</issue><spage>260</spage><epage>266</epage><pages>260-266</pages><issn>0250-8095</issn><eissn>1421-9670</eissn><coden>AJNED9</coden><abstract>Aims: Minimal change disease (MCD) is the most common primary nephrotic syndrome in children. Some suggested that interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) are involved in the pathogenesis of MCD. This study was done to see changes of plasma and urinary IL-8, TNF-α, and their effects on determination of permeability of glomerular basement membrane (BM) contributed by heparan sulfate proteoglycan (HSPG). Methods: Study patients consisted of 19 biopsy-proven MCD children aged 2–15 years old. Both plasma, urinary IL-8 and TNF-α were measured. Employing the Millicell system, IL-8 and TNF-α were screened for the permeability factors. We examined whether IL-8 and TNF-α regulated BM HSPG gene expression and HS synthesis in the glomerular epithelial cells (GECs). Results: Urinary IL-8 during relapse was significantly increased when compared with that of during remission or controls (13,996 ± 2,811 vs. 2,941 ± 373, 5,331 ± 640 ng/mg·cr) (p < 0.05). Urinary TNF-α during relapse was also significantly increased (364.4 ± 51.2 vs. 155.3 ± 20.8, 36.0 ± 4.5 ng/mg·cr) (p < 0.05). Plasma IL-8 during relapse was significantly increased compared to that during remission(1.19 ± 0.62 vs. 0.51 ± 0.42 ng/ml) (p < 0.05). However, the negative results were obtained in the permeability assay using the Millicell system. No difference was seen in BM HSPG gene expression and HS synthesis in the GECs. Conclusion: Therefore, it seems that both IL-8 and TNF-α may not play a disease-specific role in the pathogenesis of MCD.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>12840601</pmid><doi>10.1159/000072065</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of nephrology, 2003-07, Vol.23 (4), p.260-266 |
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| subjects | Adolescent Albumins - metabolism Basement Membrane - physiopathology Biological and medical sciences Child Child, Preschool Epithelium - metabolism Female Glomerulonephritis Heparan Sulfate Proteoglycans - metabolism Heparitin Sulfate - metabolism Humans Interleukin-8 - metabolism Kidney Glomerulus - metabolism Kidney Glomerulus - physiopathology Male Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Nephrosis, Lipoid - metabolism Original Article: Patient-Oriented, Translational Research Permeability Recurrence Tumor Necrosis Factor-alpha - metabolism |
| title | Interleukin-8 and Tumor Necrosis Factor-Alpha Are Increased in Minimal Change Disease but Do Not Alter Albumin Permeability |
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