Baseline Quality of Life as a Predictor of Mortality and Hospitalization in 5,025 Patients With Congestive Heart Failure
This study examined the independent relation of health-related quality of life (HRQL) to mortality and congestive heart failure (CHF)-related hospitalizations in patients with an ejection fraction of
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| Veröffentlicht in: | The American journal of cardiology 1996-10, Vol.78 (8), p.890-895 |
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| container_title | The American journal of cardiology |
| container_volume | 78 |
| creator | Konstam, Varda Salem, Deeb Pouleur, Hubert Kostis, John Gorkin, Larry Shumaker, Sally Mottard, Isabelle Woods, Pat Konstam, Marvin A. Yusuf, Salim |
| description | This study examined the independent relation of health-related quality of life (HRQL) to mortality and congestive heart failure (CHF)-related hospitalizations in patients with an ejection fraction of |
| doi_str_mv | 10.1016/S0002-9149(96)00463-8 |
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(Am J Cardiol 1996;78:890–895)]]></description><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Health</subject><subject>Heart</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>Medical sciences</subject><subject>Mortality</subject><subject>Quality of life</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNqFkF1rFDEUhoMouFZ_ghDECwsdzfdMrsQu1hW2WFHxMpzNnGjKOFmTbLH99Wa7pbe9Cu_hOR95CHnJ2VvOuHn3jTEmOsuVfWPNMWPKyG54RBZ86G3HLZePyeIeeUqelXLZIufaLMi_Uyg4xRnp1x1MsV7TFOg6BqRQKNCLjGP0NeV9-TzlemBgHukqlW3c5xuoMc00zlSfMKHpRcs410J_xvqbLtP8C0uNV0hXCLnSM4jTLuNz8iTAVPDF3XtEfpx9_L5cdesvnz4vP6w7r7iunRyU2Qyb0fZcgOw1iI1S3gaQZsRBGjRWSAg8jCIYlEwqxfteoNB60wpWHpFXh7nbnP7u2iXuMu3y3FY60fBeCc0bpA-Qz6mUjMFtc_wD-dpx5vaO3a1jtxforHG3jt3Q-l7fDYfiYQoZZh_LfbMUuhdaNuz9AcP20auI2RXfFPnmNqOvbkzxgUX_AfVhj1E</recordid><startdate>19961015</startdate><enddate>19961015</enddate><creator>Konstam, Varda</creator><creator>Salem, Deeb</creator><creator>Pouleur, Hubert</creator><creator>Kostis, John</creator><creator>Gorkin, Larry</creator><creator>Shumaker, Sally</creator><creator>Mottard, Isabelle</creator><creator>Woods, Pat</creator><creator>Konstam, Marvin A.</creator><creator>Yusuf, Salim</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope></search><sort><creationdate>19961015</creationdate><title>Baseline Quality of Life as a Predictor of Mortality and Hospitalization in 5,025 Patients With Congestive Heart Failure</title><author>Konstam, Varda ; Salem, Deeb ; Pouleur, Hubert ; Kostis, John ; Gorkin, Larry ; Shumaker, Sally ; Mottard, Isabelle ; Woods, Pat ; Konstam, Marvin A. ; Yusuf, Salim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-3846b8bd9712a375a2b44c9fa36de836e6923af1fd2f6e303441772e255bf6e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Health</topic><topic>Heart</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>Medical sciences</topic><topic>Mortality</topic><topic>Quality of life</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Konstam, Varda</creatorcontrib><creatorcontrib>Salem, Deeb</creatorcontrib><creatorcontrib>Pouleur, Hubert</creatorcontrib><creatorcontrib>Kostis, John</creatorcontrib><creatorcontrib>Gorkin, Larry</creatorcontrib><creatorcontrib>Shumaker, Sally</creatorcontrib><creatorcontrib>Mottard, Isabelle</creatorcontrib><creatorcontrib>Woods, Pat</creatorcontrib><creatorcontrib>Konstam, Marvin A.</creatorcontrib><creatorcontrib>Yusuf, Salim</creatorcontrib><creatorcontrib>SOLVD Investigators</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Konstam, Varda</au><au>Salem, Deeb</au><au>Pouleur, Hubert</au><au>Kostis, John</au><au>Gorkin, Larry</au><au>Shumaker, Sally</au><au>Mottard, Isabelle</au><au>Woods, Pat</au><au>Konstam, Marvin A.</au><au>Yusuf, Salim</au><aucorp>SOLVD Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Baseline Quality of Life as a Predictor of Mortality and Hospitalization in 5,025 Patients With Congestive Heart Failure</atitle><jtitle>The American journal of cardiology</jtitle><date>1996-10-15</date><risdate>1996</risdate><volume>78</volume><issue>8</issue><spage>890</spage><epage>895</epage><pages>890-895</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract><![CDATA[This study examined the independent relation of health-related quality of life (HRQL) to mortality and congestive heart failure (CHF)-related hospitalizations in patients with an ejection fraction of <0.35 followed for a mean of 36.5 months. A brief HRQL questionnaire was administered at baseline to patients randomized to placebo or enalapril in the Studies of Left Ventricular Dysfunction (SOLVD) trial. Participants had an ejection fraction of <0.35 and either symptomatic CHF (treatment trial, n = 2,465) or asymptomatic CHF (prevention trial, n = 2,560). Baseline assessment of HRQL predicted mortality and CHF-related hospitalizations in symptomatic and asymptomatic patients randomized to enalapril and placebo treatment. Domains that were the stronger univariate predictors of mortality and CHF-related hospitalizations were activities of daily living (relative risk [RR] for mortality: 1.163, p <0.000; for hospitalization: 1.215, p <0.000), general health (RR for mortality: 1.205, p <0.000; for hospitalization: 1.188, p <0.000), and social functioning (RR for mortality 1.098, p <0.000; for hospitalization: RR 1.156, p <0.000). In the multivariate model, activities of daily living (RR for mortality 1.41, p <0.000; for hospitalization: RR 1.43, p <0.002), general health (RR for mortality 1.21, p <0.000; for hospitalization RR 1.16, p <0.013) and heart failure symptoms (RR for mortality 1.02, p <0.025; for hospitalization RR 1.03, p <0.004) were found to be independent risk factors. HRQL independently predicted mortality and CHF-related hospitalizations after adjustment for ejection fraction, age, treatment, and New York Heart Association classification in patients with an ejection fraction of <0.35, randomized to enalapril and placebo treatment. HRQL provides additional clinical information regarding disease course and outcome that is not captured by traditional indexes of clinical status.
(Am J Cardiol 1996;78:890–895)]]></abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><doi>10.1016/S0002-9149(96)00463-8</doi><tpages>6</tpages></addata></record> |
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| ispartof | The American journal of cardiology, 1996-10, Vol.78 (8), p.890-895 |
| issn | 0002-9149 1879-1913 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Cardiology. Vascular system Cardiovascular disease Health Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Medical sciences Mortality Quality of life |
| title | Baseline Quality of Life as a Predictor of Mortality and Hospitalization in 5,025 Patients With Congestive Heart Failure |
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