Comparison of dobutamine stress echocardiography, dipyridamole stress echocardiography and exercise stress testing for diagnosis of coronary artery disease
To compare the value of dobutamine and dipyridamole stress echocardiography with exercise stress testing for the diagnosis of coronary artery disease (CAD), 80 patients with chest pain of suspected myocardial ischemic origin (57 with CAD and 23 without significant CAD) underwent dobutamine stress ec...
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| Veröffentlicht in: | The American journal of cardiology 1993-10, Vol.72 (12), p.865-870 |
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| creator | Previtali, Mario Lanzarini, Luca Fetiveau, Raffaela Poll, Arnaldo Ferrario, Maurizio Falcone, Colomba Mussini, Antonio |
| description | To compare the value of dobutamine and dipyridamole stress echocardiography with exercise stress testing for the diagnosis of coronary artery disease (CAD), 80 patients with chest pain of suspected myocardial ischemic origin (57 with CAD and 23 without significant CAD) underwent dobutamine stress echocardiography (5 to 40 μ/kg/min), dipyridamole echocardiography (0.84 mg/kg over 10 minutes) and bicycle exercise electrocardiography after discontinuation of antianginal treatment. Dobutamine echocardiography and exercise testing revealed a higher overall sensitivity than dipyridamole echocardiography (79 vs 60%, p < 0.005; 77 vs 60%, p < 0.05, respectively); this finding was due to a higher dobutamine and exercise sensitivity in 1-vessel CAD (62 vs 33%, p |
| doi_str_mv | 10.1016/0002-9149(93)91097-2 |
| format | Article |
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Dobutamine echocardiography and exercise testing revealed a higher overall sensitivity than dipyridamole echocardiography (79 vs 60%, p < 0.005; 77 vs 60%, p < 0.05, respectively); this finding was due to a higher dobutamine and exercise sensitivity in 1-vessel CAD (62 vs 33%, p <0.05 for both tests), whereas sensitivity of the 3 tests was similar in multivessel CAD. Dobutamine and dipyridamole showed a higher specificity than exercise (83 vs 43%, p < 0.01; 96 vs 43%, p < 0.005, respectively). Diagnostic accuracy of dobutamine echocardiography was higher than that of exercise (80 vs 67%, p <0.05), whereas the difference with dipyridamole (80 vs 70%) was not significant. In the tests that yielded positive results, double product during exercise was significantly higher than that during dobutamine and dipyridamole echocardiography. No major complications occurred during the tests, but adverse effects were more frequent during dobutamine testing. Thus, dobutamine echocardiography may be superior to dipyridamole echocardiography and exercise electrocardiography for the diagnosis of CAD.]]></description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/0002-9149(93)91097-2</identifier><identifier>PMID: 8213540</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Arrhythmias, Cardiac - chemically induced ; Biological and medical sciences ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Cardiology. Vascular system ; Cardiovascular disease ; Coronary Angiography ; Coronary Disease - diagnosis ; Coronary Disease - diagnostic imaging ; Coronary Disease - pathology ; Coronary Disease - physiopathology ; Coronary heart disease ; Coronary Vessels - pathology ; Dipyridamole - administration & dosage ; Dipyridamole - adverse effects ; Dobutamine - administration & dosage ; Dobutamine - adverse effects ; Echocardiography ; Electrocardiography ; Exercise Test ; Female ; Heart ; Heart Rate - drug effects ; Heart Rate - physiology ; Humans ; Infusion Pumps ; Male ; Medical research ; Medical sciences ; Middle Aged ; Myocardial Contraction - drug effects ; Myocardial Contraction - physiology ; Sensitivity and Specificity ; Stress</subject><ispartof>The American journal of cardiology, 1993-10, Vol.72 (12), p.865-870</ispartof><rights>1993</rights><rights>1994 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. 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Dobutamine echocardiography and exercise testing revealed a higher overall sensitivity than dipyridamole echocardiography (79 vs 60%, p < 0.005; 77 vs 60%, p < 0.05, respectively); this finding was due to a higher dobutamine and exercise sensitivity in 1-vessel CAD (62 vs 33%, p <0.05 for both tests), whereas sensitivity of the 3 tests was similar in multivessel CAD. Dobutamine and dipyridamole showed a higher specificity than exercise (83 vs 43%, p < 0.01; 96 vs 43%, p < 0.005, respectively). Diagnostic accuracy of dobutamine echocardiography was higher than that of exercise (80 vs 67%, p <0.05), whereas the difference with dipyridamole (80 vs 70%) was not significant. In the tests that yielded positive results, double product during exercise was significantly higher than that during dobutamine and dipyridamole echocardiography. No major complications occurred during the tests, but adverse effects were more frequent during dobutamine testing. Thus, dobutamine echocardiography may be superior to dipyridamole echocardiography and exercise electrocardiography for the diagnosis of CAD.]]></description><subject>Adult</subject><subject>Aged</subject><subject>Arrhythmias, Cardiac - chemically induced</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - diagnosis</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - pathology</subject><subject>Coronary Disease - physiopathology</subject><subject>Coronary heart disease</subject><subject>Coronary Vessels - pathology</subject><subject>Dipyridamole - administration & dosage</subject><subject>Dipyridamole - adverse effects</subject><subject>Dobutamine - administration & dosage</subject><subject>Dobutamine - adverse effects</subject><subject>Echocardiography</subject><subject>Electrocardiography</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Heart</subject><subject>Heart Rate - drug effects</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Infusion Pumps</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Contraction - drug effects</subject><subject>Myocardial Contraction - physiology</subject><subject>Sensitivity and Specificity</subject><subject>Stress</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd1qGzEQhUVpcRy3b9DAUnKRQLbV7651EygmP4VAbtJrIUuzjoJX2o7WIXmWvGzl2viuuRqG-c7M4QwhXxn9zihrflBKea2Z1GdanGtGdVvzD2TK5q2umWbiI5kekCNynPNTaRlTzYRM5pwJJemUvC1SP1gMOcUqdZVPy81o-xChyiNCzhW4x-Qs-pBWaIfH14vKh-EVg7d9Wv-Xqmz0FbwAupAP0Ah5DHFVdQnLEruKKYe8veoSpmixqHCEUnwR2QyfyafOrjN82dcZ-X199bC4re_ub34tft7VTrZ6rB2dW8-l1YIz7ZVqAASXkkvdUeY076gE8EraVivmOsoVF9wr1grVOtFIMSPfdnsHTH82xaR5ShuM5aThggoptWwKJHeQw5QzQmcGDH0xbRg123-YbdhmG7bRwvz7R5HPyMl-92bZgz-I9g8o89P93GZn1x3aWCI7YKJt-LxpC3a5w6Dk8BwATXYBogMfENxofArv-_gLBhKpsw</recordid><startdate>19931015</startdate><enddate>19931015</enddate><creator>Previtali, Mario</creator><creator>Lanzarini, Luca</creator><creator>Fetiveau, Raffaela</creator><creator>Poll, Arnaldo</creator><creator>Ferrario, Maurizio</creator><creator>Falcone, Colomba</creator><creator>Mussini, Antonio</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope></search><sort><creationdate>19931015</creationdate><title>Comparison of dobutamine stress echocardiography, dipyridamole stress echocardiography and exercise stress testing for diagnosis of coronary artery disease</title><author>Previtali, Mario ; Lanzarini, Luca ; Fetiveau, Raffaela ; Poll, Arnaldo ; Ferrario, Maurizio ; Falcone, Colomba ; Mussini, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-c08ad24a93219d556ee3244249f01c92f04eed54a7951cf025232d517357c3643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arrhythmias, Cardiac - chemically induced</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Coronary Angiography</topic><topic>Coronary Disease - diagnosis</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Disease - pathology</topic><topic>Coronary Disease - physiopathology</topic><topic>Coronary heart disease</topic><topic>Coronary Vessels - pathology</topic><topic>Dipyridamole - administration & dosage</topic><topic>Dipyridamole - adverse effects</topic><topic>Dobutamine - administration & dosage</topic><topic>Dobutamine - adverse effects</topic><topic>Echocardiography</topic><topic>Electrocardiography</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Heart</topic><topic>Heart Rate - drug effects</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Infusion Pumps</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Contraction - drug effects</topic><topic>Myocardial Contraction - physiology</topic><topic>Sensitivity and Specificity</topic><topic>Stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Previtali, Mario</creatorcontrib><creatorcontrib>Lanzarini, Luca</creatorcontrib><creatorcontrib>Fetiveau, Raffaela</creatorcontrib><creatorcontrib>Poll, Arnaldo</creatorcontrib><creatorcontrib>Ferrario, Maurizio</creatorcontrib><creatorcontrib>Falcone, Colomba</creatorcontrib><creatorcontrib>Mussini, Antonio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Previtali, Mario</au><au>Lanzarini, Luca</au><au>Fetiveau, Raffaela</au><au>Poll, Arnaldo</au><au>Ferrario, Maurizio</au><au>Falcone, Colomba</au><au>Mussini, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of dobutamine stress echocardiography, dipyridamole stress echocardiography and exercise stress testing for diagnosis of coronary artery disease</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1993-10-15</date><risdate>1993</risdate><volume>72</volume><issue>12</issue><spage>865</spage><epage>870</epage><pages>865-870</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract><![CDATA[To compare the value of dobutamine and dipyridamole stress echocardiography with exercise stress testing for the diagnosis of coronary artery disease (CAD), 80 patients with chest pain of suspected myocardial ischemic origin (57 with CAD and 23 without significant CAD) underwent dobutamine stress echocardiography (5 to 40 μ/kg/min), dipyridamole echocardiography (0.84 mg/kg over 10 minutes) and bicycle exercise electrocardiography after discontinuation of antianginal treatment. Dobutamine echocardiography and exercise testing revealed a higher overall sensitivity than dipyridamole echocardiography (79 vs 60%, p < 0.005; 77 vs 60%, p < 0.05, respectively); this finding was due to a higher dobutamine and exercise sensitivity in 1-vessel CAD (62 vs 33%, p <0.05 for both tests), whereas sensitivity of the 3 tests was similar in multivessel CAD. Dobutamine and dipyridamole showed a higher specificity than exercise (83 vs 43%, p < 0.01; 96 vs 43%, p < 0.005, respectively). Diagnostic accuracy of dobutamine echocardiography was higher than that of exercise (80 vs 67%, p <0.05), whereas the difference with dipyridamole (80 vs 70%) was not significant. In the tests that yielded positive results, double product during exercise was significantly higher than that during dobutamine and dipyridamole echocardiography. No major complications occurred during the tests, but adverse effects were more frequent during dobutamine testing. Thus, dobutamine echocardiography may be superior to dipyridamole echocardiography and exercise electrocardiography for the diagnosis of CAD.]]></abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8213540</pmid><doi>10.1016/0002-9149(93)91097-2</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Arrhythmias, Cardiac - chemically induced Biological and medical sciences Blood Pressure - drug effects Blood Pressure - physiology Cardiology. Vascular system Cardiovascular disease Coronary Angiography Coronary Disease - diagnosis Coronary Disease - diagnostic imaging Coronary Disease - pathology Coronary Disease - physiopathology Coronary heart disease Coronary Vessels - pathology Dipyridamole - administration & dosage Dipyridamole - adverse effects Dobutamine - administration & dosage Dobutamine - adverse effects Echocardiography Electrocardiography Exercise Test Female Heart Heart Rate - drug effects Heart Rate - physiology Humans Infusion Pumps Male Medical research Medical sciences Middle Aged Myocardial Contraction - drug effects Myocardial Contraction - physiology Sensitivity and Specificity Stress |
| title | Comparison of dobutamine stress echocardiography, dipyridamole stress echocardiography and exercise stress testing for diagnosis of coronary artery disease |
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