Properties of CFTR activated by the xanthine derivative X-33 in human airway Calu-3 cells

The pharmacological activation of the cystic fibrosis gene protein cystic fibrosis transmembrane conductance regulator (CFTR) was studied in human airway epithelial Calu-3 cells, which express a high level of CFTR protein as assessed by Western blot and in vitro phosphorylation. Immunolocalization s...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2000-12, Vol.48 (6), p.C1925-C1937
Hauptverfasser:	BULTEAU, Laurence, DERAND, Renaud, JOUGLA, Chantal, DORMER, Robert L, VIERFOND, Jean-Michel, JOFFRE, Michel, BECQ, Frédéric, METTEY, Yvette, METAYE, Thierry, MORRIS, M. Rachel, MCNEILLY, Ceinwen M, FOLLI, Chiara, GALIETTA, Luis J. V, ZEGARRA-MORAN, Olga, PEREIRA, Malcolm M. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and medical sciences Cell membranes. Ionic channels. Membrane pores Cell structures and functions Cells Cystic fibrosis Fundamental and applied biological sciences. Psychology Membranes Molecular and cellular biology Pharmacology
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Zusammenfassung:	The pharmacological activation of the cystic fibrosis gene protein cystic fibrosis transmembrane conductance regulator (CFTR) was studied in human airway epithelial Calu-3 cells, which express a high level of CFTR protein as assessed by Western blot and in vitro phosphorylation. Immunolocalization shows that CFTR is located in the apical membrane.
ISSN:	0363-6143 1522-1563