Dominant-negative PKC- impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini

We investigated the involvement of PKC-{epsilon} in apical actin remodeling in carbachol-stimulated exocytosis in reconstituted rabbit lacrimal acinar cells. Lacrimal acinar PKC-{epsilon} cosedimented with actin filaments in an actin filament binding assay. Stimulation of acini with carbachol (100 m...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2005-10, Vol.58 (4), p.C1052
Hauptverfasser:	Jerdeva, Galina V, Yarber, Francie A, Trousdale, Melvin D, Rhodes, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cellular biology Excretory system Inhibitor drugs Proteins Rabbits Signal transduction
Online-Zugang:	Volltext
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