Glutamate transport and cellular glutamine metabolism : regulation in LLC-PK1 vs. LLC-PK1-F+ cell lines

The glutamate (Glu) transporter may modulate cellular glutamine (Gln) metabolism by regulating both the rates of hydrolysis and subsequent conversion of Glu. to alpha-ketoglutarate and NH4+. By delivering Glu, a competitive inhibitor of Gln for the phosphate-dependent glutaminase (PDG) as well as an...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 1998-06, Vol.43 (6), p.C1616-C1624
Hauptverfasser:	MEADE, D, CHESS, C, WELBOURNE, T. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Biochemistry Biological and medical sciences Cellular biology Fundamental and applied biological sciences. Psychology Genes Molecular biology Proteins
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The glutamate (Glu) transporter may modulate cellular glutamine (Gln) metabolism by regulating both the rates of hydrolysis and subsequent conversion of Glu. to alpha-ketoglutarate and NH4+. By delivering Glu, a competitive inhibitor of Gln for the phosphate-dependent glutaminase (PDG) as well as an acid-load activator of glutamate dehydrogenase (GDH) flux, the transporter may effectively substitute extracellularly generated Glu from the gamma-glutamyltransferase for that derived intracellularly from Gln.
ISSN:	0363-6143 1522-1563