Dephosphorylation of activated protein kinase C contributes to downregulation by bryostatin

Dephosphorylation predisposes protein kinase C to proteolysis. Greater production of the 76-kDa form of protein kinase C explains the more efficient downregulation of the kinase by bryostatin versus phorbol 12-myristate 13-acetate.

Bibliographische Detailangaben

Veröffentlicht in:	American Journal of Physiology: Cell Physiology 1996-07, Vol.40 (1), p.C304-C311
Hauptverfasser:	LEE, H.-W, SMITH, L, PETTIT, G. R, BINGHAM SMITH, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Cells Cellular biology General aspects Medical sciences Pharmacology. Drug treatments Proteins
Online-Zugang:	Volltext
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