AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression

ZNF322A is an oncogenic zinc-finger transcription factor. Our published results show that ZNF322A positively regulates transcription of alpha-adducin (ADD1) and cyclin D1 (CCND1) to promote tumorgenicity of lung cancer. However, the upstream regulatory mechanisms of ZNF322A protein function remain e...

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Veröffentlicht in:	Oncogene 2019-10, Vol.38 (41), p.6723-6736
Hauptverfasser:	Liao, Sheng-You, Kuo, I-Ying, Chen, Yu-Ting, Liao, Pao-Chi, Liu, Ya-Fen, Wu, Hsin-Yi, Lai, Wu-Wei, Wang, Yi-Ching
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 13/51 13/95 631/337/458/1733 631/337/572 631/67/1612/1350 631/67/1857 631/67/395 64/60 82/1 82/29 82/80 96/106 Adducin Affinity AKT protein Apoptosis Cell Biology Cell culture Cell Line, Tumor Cell Proliferation Cellular signal transduction Chromatin Cyclin D1 Deoxyribonucleic acid Development and progression DNA Epidermal Growth Factor - metabolism Genetic aspects Genetic transcription Human Genetics Humans Immunoprecipitation Internal Medicine Kinases Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - pathology Mass spectroscopy Medicine Medicine & Public Health Metastases Neoplasm Metastasis Oncogene Proteins - metabolism Oncology Patients Phosphorylation Prognosis Promoter Regions, Genetic Protein Stability Proteins Proto-Oncogene Proteins c-akt - metabolism Signal Transduction Transcription Factors - metabolism Transcription, Genetic Xenografts Zinc finger proteins
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