Genome‐wide interaction study of early‐life smoking exposure on time‐to‐asthma onset in childhood

Background Asthma, a heterogeneous disease with variable age of onset, results from the interplay between genetic and environmental factors. Early‐life tobacco smoke (ELTS) exposure is a major asthma risk factor. Only a few genetic loci have been reported to interact with ELTS exposure in asthma. Ob...

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Veröffentlicht in:	Clinical and experimental allergy 2019-10, Vol.49 (10), p.1342-1351
Hauptverfasser:	Sugier, Pierre‐Emmanuel, Sarnowski, Chloé, Granell, Raquel, Laprise, Catherine, Ege, Markus J., Margaritte‐Jeannin, Patricia, Dizier, Marie‐Hélène, Minelli, Cosetta, Moffatt, Miriam F., Lathrop, Mark, Cookson, William O. C. M., Henderson, A. John, Mutius, Erika, Kogevinas, Manolis, Demenais, Florence, Bouzigon, Emmanuelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Asthma Asthma - genetics Child Childhood childhood asthma Children Chromosome 13 Chromosome 20 CpG islands Cytochrome P-450 CYP1B1 - genetics Cytoskeletal Proteins - genetics DNA methylation DNA Repair Enzymes - genetics Environmental factors environmental tobacco smoke exposure Exposure Female Gene loci Genetic Predisposition to Disease gene‐environment interaction Genome-Wide Association Study Genomes Health risks Humans Hydrolases - genetics Male Microfilament Proteins - genetics Nuclear Proteins - genetics Polymorphism, Single Nucleotide Risk factors Single-nucleotide polymorphism Smoke Smoking time‐to‐asthma onset Tobacco Tobacco smoke Tobacco Smoke Pollution - adverse effects
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