Sodium Butyrate Inhibits Carcinoma Development in a 1,2-Dimethylhydrazine-Induced Rat Colon Cancer
Background: Butyric acid is one of the most important by-products of dietary fiber degradation. It is an important trophic agent for the intestinal mucosa under different experimental conditions. Data obtained from several in vitro studies strongly suggest that butyrate can be a potential therapeuti...
Gespeichert in:
| Veröffentlicht in: | JPEN. Journal of parenteral and enteral nutrition 1998-01, Vol.22 (1), p.14-17 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 17 |
|---|---|
| container_issue | 1 |
| container_start_page | 14 |
| container_title | JPEN. Journal of parenteral and enteral nutrition |
| container_volume | 22 |
| creator | Medina, V. Afonso, J.J. Alvarez-Arguelles, H. Hernández, C. González, F. |
| description | Background: Butyric acid is one of the most important by-products of dietary fiber degradation. It is an important trophic agent for the intestinal mucosa under different experimental conditions. Data obtained from several in vitro studies strongly suggest that butyrate can be a potential therapeutic agent in controlling the growth of some cancer cells. However, to date, in vivo animal studies have failed to show conclusive results. Methods: We evaluated the effects of intracecal administration of butyrate in an experimental model of colonic carcinogenesis induced by 1,2-dimethylhydrazine (DMH), administered at the site where it is naturally produced, the cecum. We studied the incidence of colon tumors and their main histologic features. Results: Direct application of sodium butyrate significantly decreased the total number of tumors and the incidence of malignancies and carcinoma in the colon. Conclusions: Butyrate may inhibit the growth of tumors induced by DMH. (Journal of Parenteral and Enteral Nutrition
22: 14-17, 1998) |
| doi_str_mv | 10.1177/014860719802200114 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_230215057</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_014860719802200114</sage_id><sourcerecordid>25230707</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5094-fd2d79f7777f55ef96597577241cbf12a06fe241044178a2711f6bf84f2b93733</originalsourceid><addsrcrecordid>eNqNkEFP3DAQha2KCpZt_0AlJAtxJDDjOHFyLAuUrVCLaHuOnMTuGiXOYidF4dfjaFfLAQnVF9uab968eYR8QThDFOIckGcpCMwzYAwAkX8gM8w5RoxzvkdmExBNxAE59P4BAOIUYJ_s5zwWKc9mpPzV1WZo6cXQj072ii7typSm93QhXWVs10p6qf6pplu3yvbUWCopnrLo0rSqX43NaqydfDZWRUtbD5Wq6b3s6aJrOhskbKXcJ_JRy8arz9t7Tv5cX_1e3ES3P78tF19voyqBnEe6ZrXItQhHJ4nSeZrkIhGCcaxKjUxCqlX4AOcoMskEok5LnXHNyjwWcTwnxxvdteseB-X74qEbnA0jCxYDwwQSESC2gSrXee-ULtbOtNKNBUIxhVq8DTU0HW2Vh7JV9a5lm2Kon2zr0ley0S7sbfwOY4hJyieD2QZ7Mo0a_2Nw8f3u6kd4TQ7ON61e_lWve73j-QX3pplK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>230215057</pqid></control><display><type>article</type><title>Sodium Butyrate Inhibits Carcinoma Development in a 1,2-Dimethylhydrazine-Induced Rat Colon Cancer</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Medina, V. ; Afonso, J.J. ; Alvarez-Arguelles, H. ; Hernández, C. ; González, F.</creator><creatorcontrib>Medina, V. ; Afonso, J.J. ; Alvarez-Arguelles, H. ; Hernández, C. ; González, F.</creatorcontrib><description>Background: Butyric acid is one of the most important by-products of dietary fiber degradation. It is an important trophic agent for the intestinal mucosa under different experimental conditions. Data obtained from several in vitro studies strongly suggest that butyrate can be a potential therapeutic agent in controlling the growth of some cancer cells. However, to date, in vivo animal studies have failed to show conclusive results. Methods: We evaluated the effects of intracecal administration of butyrate in an experimental model of colonic carcinogenesis induced by 1,2-dimethylhydrazine (DMH), administered at the site where it is naturally produced, the cecum. We studied the incidence of colon tumors and their main histologic features. Results: Direct application of sodium butyrate significantly decreased the total number of tumors and the incidence of malignancies and carcinoma in the colon. Conclusions: Butyrate may inhibit the growth of tumors induced by DMH. (Journal of Parenteral and Enteral Nutrition
22: 14-17, 1998)</description><identifier>ISSN: 0148-6071</identifier><identifier>EISSN: 1941-2444</identifier><identifier>DOI: 10.1177/014860719802200114</identifier><identifier>PMID: 9437648</identifier><identifier>CODEN: JPENDU</identifier><language>eng</language><publisher>Thousand Oaks, CA: Sage Publications</publisher><subject>1,2-Dimethylhydrazine - toxicity ; Adenoma - chemically induced ; Adenoma - pathology ; Adenoma - prevention & control ; Animal Nutritional Physiological Phenomena ; Animals ; Antineoplastic agents ; Biological and medical sciences ; Butyrates - administration & dosage ; Butyrates - therapeutic use ; Butyric Acid ; Carcinogens - toxicity ; Carcinoma - chemically induced ; Carcinoma - pathology ; Carcinoma - prevention & control ; Chemotherapy ; Cohort Studies ; Colonic Neoplasms - chemically induced ; Colonic Neoplasms - prevention & control ; Disease Models, Animal ; Histamine Antagonists - administration & dosage ; Histamine Antagonists - therapeutic use ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Random Allocation ; Rats ; Rats, Sprague-Dawley</subject><ispartof>JPEN. Journal of parenteral and enteral nutrition, 1998-01, Vol.22 (1), p.14-17</ispartof><rights>1998 by The American Society for Parenteral and Enteral Nutrition</rights><rights>1998 INIST-CNRS</rights><rights>Copyright American Society for Parenteral and Enteral Nutrition Jan/Feb 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5094-fd2d79f7777f55ef96597577241cbf12a06fe241044178a2711f6bf84f2b93733</citedby><cites>FETCH-LOGICAL-c5094-fd2d79f7777f55ef96597577241cbf12a06fe241044178a2711f6bf84f2b93733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1177%2F014860719802200114$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1177%2F014860719802200114$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1417,4050,4051,23930,23931,25140,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2115643$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9437648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Medina, V.</creatorcontrib><creatorcontrib>Afonso, J.J.</creatorcontrib><creatorcontrib>Alvarez-Arguelles, H.</creatorcontrib><creatorcontrib>Hernández, C.</creatorcontrib><creatorcontrib>González, F.</creatorcontrib><title>Sodium Butyrate Inhibits Carcinoma Development in a 1,2-Dimethylhydrazine-Induced Rat Colon Cancer</title><title>JPEN. Journal of parenteral and enteral nutrition</title><addtitle>JPEN J Parenter Enteral Nutr</addtitle><description>Background: Butyric acid is one of the most important by-products of dietary fiber degradation. It is an important trophic agent for the intestinal mucosa under different experimental conditions. Data obtained from several in vitro studies strongly suggest that butyrate can be a potential therapeutic agent in controlling the growth of some cancer cells. However, to date, in vivo animal studies have failed to show conclusive results. Methods: We evaluated the effects of intracecal administration of butyrate in an experimental model of colonic carcinogenesis induced by 1,2-dimethylhydrazine (DMH), administered at the site where it is naturally produced, the cecum. We studied the incidence of colon tumors and their main histologic features. Results: Direct application of sodium butyrate significantly decreased the total number of tumors and the incidence of malignancies and carcinoma in the colon. Conclusions: Butyrate may inhibit the growth of tumors induced by DMH. (Journal of Parenteral and Enteral Nutrition
22: 14-17, 1998)</description><subject>1,2-Dimethylhydrazine - toxicity</subject><subject>Adenoma - chemically induced</subject><subject>Adenoma - pathology</subject><subject>Adenoma - prevention & control</subject><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Butyrates - administration & dosage</subject><subject>Butyrates - therapeutic use</subject><subject>Butyric Acid</subject><subject>Carcinogens - toxicity</subject><subject>Carcinoma - chemically induced</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - prevention & control</subject><subject>Chemotherapy</subject><subject>Cohort Studies</subject><subject>Colonic Neoplasms - chemically induced</subject><subject>Colonic Neoplasms - prevention & control</subject><subject>Disease Models, Animal</subject><subject>Histamine Antagonists - administration & dosage</subject><subject>Histamine Antagonists - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0148-6071</issn><issn>1941-2444</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkEFP3DAQha2KCpZt_0AlJAtxJDDjOHFyLAuUrVCLaHuOnMTuGiXOYidF4dfjaFfLAQnVF9uab968eYR8QThDFOIckGcpCMwzYAwAkX8gM8w5RoxzvkdmExBNxAE59P4BAOIUYJ_s5zwWKc9mpPzV1WZo6cXQj072ii7typSm93QhXWVs10p6qf6pplu3yvbUWCopnrLo0rSqX43NaqydfDZWRUtbD5Wq6b3s6aJrOhskbKXcJ_JRy8arz9t7Tv5cX_1e3ES3P78tF19voyqBnEe6ZrXItQhHJ4nSeZrkIhGCcaxKjUxCqlX4AOcoMskEok5LnXHNyjwWcTwnxxvdteseB-X74qEbnA0jCxYDwwQSESC2gSrXee-ULtbOtNKNBUIxhVq8DTU0HW2Vh7JV9a5lm2Kon2zr0ley0S7sbfwOY4hJyieD2QZ7Mo0a_2Nw8f3u6kd4TQ7ON61e_lWve73j-QX3pplK</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>Medina, V.</creator><creator>Afonso, J.J.</creator><creator>Alvarez-Arguelles, H.</creator><creator>Hernández, C.</creator><creator>González, F.</creator><general>Sage Publications</general><general>SAGE Publications</general><general>ASPEN</general><general>American Society for Parenteral and Enteral Nutrition</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>199801</creationdate><title>Sodium Butyrate Inhibits Carcinoma Development in a 1,2-Dimethylhydrazine-Induced Rat Colon Cancer</title><author>Medina, V. ; Afonso, J.J. ; Alvarez-Arguelles, H. ; Hernández, C. ; González, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5094-fd2d79f7777f55ef96597577241cbf12a06fe241044178a2711f6bf84f2b93733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>1,2-Dimethylhydrazine - toxicity</topic><topic>Adenoma - chemically induced</topic><topic>Adenoma - pathology</topic><topic>Adenoma - prevention & control</topic><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Butyrates - administration & dosage</topic><topic>Butyrates - therapeutic use</topic><topic>Butyric Acid</topic><topic>Carcinogens - toxicity</topic><topic>Carcinoma - chemically induced</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - prevention & control</topic><topic>Chemotherapy</topic><topic>Cohort Studies</topic><topic>Colonic Neoplasms - chemically induced</topic><topic>Colonic Neoplasms - prevention & control</topic><topic>Disease Models, Animal</topic><topic>Histamine Antagonists - administration & dosage</topic><topic>Histamine Antagonists - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Medina, V.</creatorcontrib><creatorcontrib>Afonso, J.J.</creatorcontrib><creatorcontrib>Alvarez-Arguelles, H.</creatorcontrib><creatorcontrib>Hernández, C.</creatorcontrib><creatorcontrib>González, F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>JPEN. Journal of parenteral and enteral nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Medina, V.</au><au>Afonso, J.J.</au><au>Alvarez-Arguelles, H.</au><au>Hernández, C.</au><au>González, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sodium Butyrate Inhibits Carcinoma Development in a 1,2-Dimethylhydrazine-Induced Rat Colon Cancer</atitle><jtitle>JPEN. Journal of parenteral and enteral nutrition</jtitle><addtitle>JPEN J Parenter Enteral Nutr</addtitle><date>1998-01</date><risdate>1998</risdate><volume>22</volume><issue>1</issue><spage>14</spage><epage>17</epage><pages>14-17</pages><issn>0148-6071</issn><eissn>1941-2444</eissn><coden>JPENDU</coden><abstract>Background: Butyric acid is one of the most important by-products of dietary fiber degradation. It is an important trophic agent for the intestinal mucosa under different experimental conditions. Data obtained from several in vitro studies strongly suggest that butyrate can be a potential therapeutic agent in controlling the growth of some cancer cells. However, to date, in vivo animal studies have failed to show conclusive results. Methods: We evaluated the effects of intracecal administration of butyrate in an experimental model of colonic carcinogenesis induced by 1,2-dimethylhydrazine (DMH), administered at the site where it is naturally produced, the cecum. We studied the incidence of colon tumors and their main histologic features. Results: Direct application of sodium butyrate significantly decreased the total number of tumors and the incidence of malignancies and carcinoma in the colon. Conclusions: Butyrate may inhibit the growth of tumors induced by DMH. (Journal of Parenteral and Enteral Nutrition
22: 14-17, 1998)</abstract><cop>Thousand Oaks, CA</cop><pub>Sage Publications</pub><pmid>9437648</pmid><doi>10.1177/014860719802200114</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-6071 |
| ispartof | JPEN. Journal of parenteral and enteral nutrition, 1998-01, Vol.22 (1), p.14-17 |
| issn | 0148-6071 1941-2444 |
| language | eng |
| recordid | cdi_proquest_journals_230215057 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | 1,2-Dimethylhydrazine - toxicity Adenoma - chemically induced Adenoma - pathology Adenoma - prevention & control Animal Nutritional Physiological Phenomena Animals Antineoplastic agents Biological and medical sciences Butyrates - administration & dosage Butyrates - therapeutic use Butyric Acid Carcinogens - toxicity Carcinoma - chemically induced Carcinoma - pathology Carcinoma - prevention & control Chemotherapy Cohort Studies Colonic Neoplasms - chemically induced Colonic Neoplasms - prevention & control Disease Models, Animal Histamine Antagonists - administration & dosage Histamine Antagonists - therapeutic use Male Medical sciences Pharmacology. Drug treatments Random Allocation Rats Rats, Sprague-Dawley |
| title | Sodium Butyrate Inhibits Carcinoma Development in a 1,2-Dimethylhydrazine-Induced Rat Colon Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T03%3A42%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sodium%20Butyrate%20Inhibits%20Carcinoma%20Development%20in%20a%201,2-Dimethylhydrazine-Induced%20Rat%20Colon%20Cancer&rft.jtitle=JPEN.%20Journal%20of%20parenteral%20and%20enteral%20nutrition&rft.au=Medina,%20V.&rft.date=1998-01&rft.volume=22&rft.issue=1&rft.spage=14&rft.epage=17&rft.pages=14-17&rft.issn=0148-6071&rft.eissn=1941-2444&rft.coden=JPENDU&rft_id=info:doi/10.1177/014860719802200114&rft_dat=%3Cproquest_cross%3E25230707%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=230215057&rft_id=info:pmid/9437648&rft_sage_id=10.1177_014860719802200114&rfr_iscdi=true |