Thyroid hormone treatment alleviates the impairments of neurogenesis, mitochondrial biogenesis and memory performance induced by methamphetamine

•Repeated MA exposure induced cognitive deficits.•MA induced impairments in neurogenesis and mitochondrial biogenesis.•MA induced neuroinflammation in the hippocampus of rats.•THs administration decreased cognitive deficits mediated by MA.•THs partially decreased alterations induced by MA in the mol...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2019-09, Vol.74, p.7-18
Hauptverfasser:	Seyedhosseini Tamijani, Seyedeh Masoumeh, Beirami, Elmira, Ahmadiani, Abolhassan, Dargahi, Leila
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cognition Animal models Animals Behavior, Animal - drug effects Behavioral plasticity Biosynthesis Central Nervous System Stimulants - toxicity Cognition Cognition - drug effects Cognition Disorders - chemically induced Cognition Disorders - prevention & control Cognition Disorders - psychology Cognitive ability Cognitive deficits Cyclooxygenase-2 Doublecortin protein Drug abuse Glial fibrillary acidic protein Hippocampus - drug effects Hippocampus - metabolism Hormones Inflammation Inflammation - chemically induced Inflammation - prevention & control Male Memory Disorders - chemically induced Memory Disorders - prevention & control Memory Disorders - psychology Menopause Methamphetamine Methamphetamine - toxicity Mitochondria Mitochondrial biogenesis Neurogenesis Neurogenesis - drug effects Neurotoxicity Neurotrophic factors Neurotrophin 3 Organelle Biogenesis Plasticity Psychomotor Performance - drug effects Radioimmunoassay Rats Rats, Wistar Reelin protein Synapses - drug effects Synaptic plasticity Thyroid Thyroid gland Thyroid hormones Thyroid Hormones - blood Thyroid Hormones - therapeutic use Thyroxine Thyroxine - therapeutic use Triiodothyronine Triiodothyronine - therapeutic use
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