Changes in neuronal activity in rat primary cortical cultures induced by illicit drugs and new psychoactive substances (NPS) following prolonged exposure and washout to mimic human exposure scenarios

•New psychoactive substances (NPS) inhibit neuronal activity following acute exposure.•Prolonged NPS exposure did not exacerbate this concentration-dependent inhibition.•Effects of several NPS were only partly reversible following washout.•Washout of methylone increased neuronal activity at human-re...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurotoxicology (Park Forest South) 2019-09, Vol.74, p.28-39
Hauptverfasser:	Zwartsen, Anne, Hondebrink, Laura, Westerink, Remco HS
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute effects Amphetamines Amphetamines - toxicity Animals Cell Survival - drug effects Central Nervous System Stimulants - toxicity Cerebral Cortex - cytology Cerebral Cortex - drug effects Cocaine Cortex Designer drugs Designer Drugs - chemistry Designer Drugs - toxicity Drug abuse Drugs Drugs of abuse Exposure Hallucinogens Health risks Humans Illicit Drugs - chemistry Illicit Drugs - toxicity Investigations Low concentrations MDMA Methamphetamine Microelectrodes Monoamine transporter Narcotics Neurons - drug effects Neurotoxicology Polymethylmethacrylate Primary Cell Culture Psychotropic Drugs - chemistry Psychotropic Drugs - toxicity Rats Receptors Stimulants Structure-Activity Relationship Structure-activity relationships
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!