LncRNA HOTAIR Regulates CCND1 and CCND2 Expression by Sponging miR-206 in Ovarian Cancer

Background/Aims: The long noncoding RNA homeobox (HOX) transcript antisense intergenic RNA (HOTAIR) has been demonstrated to be a vital modulator in the proliferation and metastasis of ovarian cancer cells, but its potential molecular mechanism remains to be elucidated. In the current study, we aime...

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Veröffentlicht in:	Cellular Physiology and Biochemistry 2018-10, Vol.49 (4), p.1289-1303
Hauptverfasser:	Chang, Lei , Guo, Ruixia, Yuan, Zhongfu, Shi, Huirong, Zhang, Dongya
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Antagomirs - metabolism Base Sequence Bone cancer CCND1 CCND2 Cell cycle Cell Line, Tumor Cell Movement Cyclin D1 - antagonists & inhibitors Cyclin D1 - genetics Cyclin D1 - metabolism Cyclin D2 - antagonists & inhibitors Cyclin D2 - genetics Cyclin D2 - metabolism Female G1 Phase Cell Cycle Checkpoints Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Genomes Gynecology Health aspects Homeobox genes Homeotic genes Humans LncRNA HOTAIR Medical prognosis Membranes Metastasis MicroRNA MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miR-206 Original Paper Ovarian cancer Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Proteins RNA Interference RNA, Long Noncoding - antagonists & inhibitors RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Small Interfering - metabolism Sequence Alignment Thermal cycling Tumors
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