Chronic Exposure of the Oligochaete Lumbriculus variegatus to Polycyclic Aromatic Compounds (PACs): Bioavailability and Effects on Reproduction
This study aimed to monitor PAC availability to the oligochaete Lumbriculus variegatus during 28 days of exposure to spiked sediments, in order to obtain reliable chronic effect concentrations for reproduction. Sediment toxicity tests were performed using three pairs of PAC isomers: two homocyclic c...
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| Veröffentlicht in: | Environmental science & technology 2008-05, Vol.42 (9), p.3434-3440 |
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| creator | Paumen, Miriam León Stol, Paul Ter Laak, Thomas L Kraak, Michiel H. S van Gestel, Cornelius A. M Admiraal, Wim |
| description | This study aimed to monitor PAC availability to the oligochaete Lumbriculus variegatus during 28 days of exposure to spiked sediments, in order to obtain reliable chronic effect concentrations for reproduction. Sediment toxicity tests were performed using three pairs of PAC isomers: two homocyclic compounds (anthracene and phenanthrene), two azaarenes (acridine and phenanthridine), and the two main transformation products of the azaarenes (acridone and phenanthridone). During the experiment, available PAC concentrations in pore water (estimated using solid phase microextraction) decreased more than total PAC concentrations in the sediment. Relating effect concentrations to PAC concentrations in pore water and in organisms showed that the two homocyclic compounds caused narcotic effects during chronic exposure, but only one of the four tested heterocyclic PACs caused narcotic effects. The transformation product phenanthridone was not toxic at the tested concentrations (up to 4000 µmol/kg dry sediment), whereas EC50 values for the parent compound phenanthridine and the isomer acridone were below the estimated limit for narcosis, suggesting a specific mode of action. These results demonstrated the unpredictable (isomer) specific toxicity of azaarenes and their transformation products, emphasizing the need of chronic toxicity testing to gain insight into the long-term effects of heterocyclic PACs, which have been overlooked in risk assessment. |
| doi_str_mv | 10.1021/es702500t |
| format | Article |
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Relating effect concentrations to PAC concentrations in pore water and in organisms showed that the two homocyclic compounds caused narcotic effects during chronic exposure, but only one of the four tested heterocyclic PACs caused narcotic effects. The transformation product phenanthridone was not toxic at the tested concentrations (up to 4000 µmol/kg dry sediment), whereas EC50 values for the parent compound phenanthridine and the isomer acridone were below the estimated limit for narcosis, suggesting a specific mode of action. These results demonstrated the unpredictable (isomer) specific toxicity of azaarenes and their transformation products, emphasizing the need of chronic toxicity testing to gain insight into the long-term effects of heterocyclic PACs, which have been overlooked in risk assessment.</description><identifier>ISSN: 0013-936X</identifier><identifier>EISSN: 1520-5851</identifier><identifier>DOI: 10.1021/es702500t</identifier><identifier>PMID: 18522130</identifier><identifier>CODEN: ESTHAG</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Acridines - analysis ; Acridones ; Animal reproduction ; Animals ; Anthracenes - analysis ; Applied sciences ; Bioavailability ; Biological Availability ; Chemical compounds ; Dose-Response Relationship, Drug ; Ecotoxicology and Human Environmental Health ; Environmental Monitoring - methods ; Exact sciences and technology ; Kinetics ; Narcotics ; Narcotics - chemistry ; Oligochaeta - drug effects ; Phenanthrenes - analysis ; Pollution ; Polycyclic aromatic hydrocarbons ; Polycyclic Aromatic Hydrocarbons - analysis ; Risk Assessment ; Sediments ; Toxicity ; Water - chemistry ; Water Pollutants, Chemical - analysis ; Worms</subject><ispartof>Environmental science & technology, 2008-05, Vol.42 (9), p.3434-3440</ispartof><rights>Copyright © 2008 American Chemical Society</rights><rights>2008 INIST-CNRS</rights><rights>Copyright American Chemical Society May 1, 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a358t-dc286e140715bcc119b933e3e44bd5202fa85ce614398ef30cc96b84c086e1733</citedby><cites>FETCH-LOGICAL-a358t-dc286e140715bcc119b933e3e44bd5202fa85ce614398ef30cc96b84c086e1733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/es702500t$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/es702500t$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20310219$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18522130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paumen, Miriam León</creatorcontrib><creatorcontrib>Stol, Paul</creatorcontrib><creatorcontrib>Ter Laak, Thomas L</creatorcontrib><creatorcontrib>Kraak, Michiel H. 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During the experiment, available PAC concentrations in pore water (estimated using solid phase microextraction) decreased more than total PAC concentrations in the sediment. Relating effect concentrations to PAC concentrations in pore water and in organisms showed that the two homocyclic compounds caused narcotic effects during chronic exposure, but only one of the four tested heterocyclic PACs caused narcotic effects. The transformation product phenanthridone was not toxic at the tested concentrations (up to 4000 µmol/kg dry sediment), whereas EC50 values for the parent compound phenanthridine and the isomer acridone were below the estimated limit for narcosis, suggesting a specific mode of action. 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S</creator><creator>van Gestel, Cornelius A. M</creator><creator>Admiraal, Wim</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope></search><sort><creationdate>20080501</creationdate><title>Chronic Exposure of the Oligochaete Lumbriculus variegatus to Polycyclic Aromatic Compounds (PACs): Bioavailability and Effects on Reproduction</title><author>Paumen, Miriam León ; Stol, Paul ; Ter Laak, Thomas L ; Kraak, Michiel H. S ; van Gestel, Cornelius A. M ; Admiraal, Wim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a358t-dc286e140715bcc119b933e3e44bd5202fa85ce614398ef30cc96b84c086e1733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acridines - analysis</topic><topic>Acridones</topic><topic>Animal reproduction</topic><topic>Animals</topic><topic>Anthracenes - analysis</topic><topic>Applied sciences</topic><topic>Bioavailability</topic><topic>Biological Availability</topic><topic>Chemical compounds</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ecotoxicology and Human Environmental Health</topic><topic>Environmental Monitoring - methods</topic><topic>Exact sciences and technology</topic><topic>Kinetics</topic><topic>Narcotics</topic><topic>Narcotics - chemistry</topic><topic>Oligochaeta - drug effects</topic><topic>Phenanthrenes - analysis</topic><topic>Pollution</topic><topic>Polycyclic aromatic hydrocarbons</topic><topic>Polycyclic Aromatic Hydrocarbons - analysis</topic><topic>Risk Assessment</topic><topic>Sediments</topic><topic>Toxicity</topic><topic>Water - chemistry</topic><topic>Water Pollutants, Chemical - analysis</topic><topic>Worms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paumen, Miriam León</creatorcontrib><creatorcontrib>Stol, Paul</creatorcontrib><creatorcontrib>Ter Laak, Thomas L</creatorcontrib><creatorcontrib>Kraak, Michiel H. S</creatorcontrib><creatorcontrib>van Gestel, Cornelius A. 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S</au><au>van Gestel, Cornelius A. M</au><au>Admiraal, Wim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic Exposure of the Oligochaete Lumbriculus variegatus to Polycyclic Aromatic Compounds (PACs): Bioavailability and Effects on Reproduction</atitle><jtitle>Environmental science & technology</jtitle><addtitle>Environ. Sci. Technol</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>42</volume><issue>9</issue><spage>3434</spage><epage>3440</epage><pages>3434-3440</pages><issn>0013-936X</issn><eissn>1520-5851</eissn><coden>ESTHAG</coden><abstract>This study aimed to monitor PAC availability to the oligochaete Lumbriculus variegatus during 28 days of exposure to spiked sediments, in order to obtain reliable chronic effect concentrations for reproduction. Sediment toxicity tests were performed using three pairs of PAC isomers: two homocyclic compounds (anthracene and phenanthrene), two azaarenes (acridine and phenanthridine), and the two main transformation products of the azaarenes (acridone and phenanthridone). During the experiment, available PAC concentrations in pore water (estimated using solid phase microextraction) decreased more than total PAC concentrations in the sediment. Relating effect concentrations to PAC concentrations in pore water and in organisms showed that the two homocyclic compounds caused narcotic effects during chronic exposure, but only one of the four tested heterocyclic PACs caused narcotic effects. The transformation product phenanthridone was not toxic at the tested concentrations (up to 4000 µmol/kg dry sediment), whereas EC50 values for the parent compound phenanthridine and the isomer acridone were below the estimated limit for narcosis, suggesting a specific mode of action. These results demonstrated the unpredictable (isomer) specific toxicity of azaarenes and their transformation products, emphasizing the need of chronic toxicity testing to gain insight into the long-term effects of heterocyclic PACs, which have been overlooked in risk assessment.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>18522130</pmid><doi>10.1021/es702500t</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Environmental science & technology, 2008-05, Vol.42 (9), p.3434-3440 |
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| subjects | Acridines - analysis Acridones Animal reproduction Animals Anthracenes - analysis Applied sciences Bioavailability Biological Availability Chemical compounds Dose-Response Relationship, Drug Ecotoxicology and Human Environmental Health Environmental Monitoring - methods Exact sciences and technology Kinetics Narcotics Narcotics - chemistry Oligochaeta - drug effects Phenanthrenes - analysis Pollution Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - analysis Risk Assessment Sediments Toxicity Water - chemistry Water Pollutants, Chemical - analysis Worms |
| title | Chronic Exposure of the Oligochaete Lumbriculus variegatus to Polycyclic Aromatic Compounds (PACs): Bioavailability and Effects on Reproduction |
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