Sirolimus and cyclosporine A alter barrier function in renal proximal tubular cells through stimulation of ERK1/2 signaling and claudin-1 expression

Alteration of the tight junction complex in renal epithelial cells can affect renal barrier function and perturb normal kidney homeostasis. The immunosuppressant drugs cyclosporine A (CsA) and sirolimus (SRL) used in combination demonstrated beneficial effects in organ transplantation but this combi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Renal physiology 2010-03, Vol.298 (3), p.F672-F682
Hauptverfasser:	Martin-Martin, Natalia, Ryan, Gavin, McMorrow, Tara, Ryan, Michael P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Butadienes - pharmacology Cell growth Cells Claudin-1 Claudin-4 Cyclosporine - toxicity Drug Synergism Electric Impedance Enzyme Activation Epithelial Cells - drug effects Epithelial Cells - enzymology Gene expression Immunosuppressive Agents - toxicity Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - enzymology Kidneys LLC-PK1 Cells Mammals Membrane Proteins - metabolism Membranes Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - metabolism Nitriles - pharmacology Permeability Phosphorylation Protein Kinase Inhibitors - pharmacology Protein Transport Proteins Signal transduction Signal Transduction - drug effects Sirolimus - toxicity Swine Tight Junctions - drug effects Tight Junctions - enzymology Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!