Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule

The purpose of this study was to evaluate the physiological significance of a tissue renin-angiotensin system in the proximal tubule of the kidney. To accomplish this, we produced mice that express human renin (hREN) under the control of the kidney androgen-regulated promoter (KAP), which is androge...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2004-05, Vol.55 (5), p.F965-F971
Hauptverfasser:	LAVOIE, Julie L, LAKE-BRUSE, Kristy D, SIGMUND, Curt D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood pressure Fundamental and applied biological sciences. Psychology Gene expression Hormones Kidneys Proteases Transgenic animals Vertebrates: urinary system
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