WNK kinases influence TRPV4 channel function and localization

TRPV4, a renally expressed nonselective cation channel of the transient receptor potential (TRP) family, is gated by hypotonicity. Kinases of the WNK family influence expression and function of the thiazide-sensitive Na+-Cl- cotransporter, and monogenic human hypertension has been linked to mutation...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2006-06, Vol.59 (6), p.F1305
Hauptverfasser:	Fu, Yi, Subramanya, Arohan, Rozansky, David, Cohen, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Enzymes Gene expression Hypertension Kidneys Mutation Signal transduction
Online-Zugang:	Volltext
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