Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation

Chronic hyperglycemia causes structural alterations of proteins through the Maillard reaction. In diabetes, methylglyoxal (MGO)-induced hydroimidazolones are the predominant modification. In contrast to acute hyperglycemia, mitochondrial respiration is depressed in chronic diabetes. To determine whe...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2005-08, Vol.58 (2), p.F420-F430
Hauptverfasser:	ROSCA, Mariana G, MUSTATA, Tiberiu G, KINTER, Michael T, OZDEMIR, Aylin M, KERN, Timothy S, SZWEDA, Luke I, BROWNLEE, Michael, MONNIER, Vincent M, WEISS, Miriam F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Diabetes Fundamental and applied biological sciences. Psychology Kidneys Mitochondrial DNA Proteins Rodents Vertebrates: urinary system
Online-Zugang:	Volltext
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