Natural conjugated linoleic acid enriched lamb meat fat modifies tissue fatty acid profile and increases n-3 HUFA score in obese Zucker rats

[...]an enhanced n-3 HUFA score reflects an increase of n-3/n-6 HUFA ratio in tissues, which has been associated with several health benefits(4). To compare the activity of different lamb meat fats with dissimilar fatty acid profile on lipid metabolism, by GC and HPLC analyses(2), Zucker rats (n = 6/group), an animal model of obesity, were fed for four weeks with four diets, three containing lamb meat fat: A) enriched in CLA; B) enriched in ALA; C) relatively low in both; and fourth diet (D) based on a mixture of olive and corn oils fat. Different letters indicate significant differences among diets, one-way ANOVA Tukey's post hoc multiple comparisons test (P < 0,05) Liver Heart VAT SAT Plasma Hypothalamus diets mean ± SE mean ± SE mean ± SE mean ± SE mean ± SE mean ± SE A 32,0 0,83a 34,6 0,26a 22,8 2,41a 23,7 1,03a 22,8 0,91a 49,8 0,86a B 30,3 0,59a 31,9 1,06a 23,5 0,81a 22,2 0,95a 21,2 0,72b 48,9 0,11a C 28,1 0,19b 32,0 1,10a 19,3 0,97a 18,9 0,67b 20,2 0,33bc 48,3 0,18a D 24,4 0,23c 25,1 0,69b 14,2 1,07b 12,8 0,68c 16,2 0,02c 47,6 0,22b We may conclude that animal fat nutritional values were strongly influenced by animal dietary regimen and the subsequent increase of dietary CLA and ALA significantly increased the tissue n-3 HUFA score, which has been shown in humans to be inversely correlated to CVD. [...]rather than focus the attention on animal fat, it should be considered the dietary fat profile irrespective of their origin. 1.