α2-Adrenoceptors Coordinate Swallowing and Respiration
Because the discoordination between swallowing and respiration may cause severe respiratory disorders such as aspiration pneumonia, understanding the neuronal mechanisms underlying such coordination is important. Recently, it was reported that medullary noradrenergic neurons are involved in evoking...
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Veröffentlicht in: | Journal of dental research 2010-03, Vol.89 (3), p.258-263 |
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creator | Yamanishi, T. Takao, K. Koizumi, H. Ishihama, K. Nohara, K. Komaki, M. Enomoto, A. Yokota, Y. Kogo, M. |
description | Because the discoordination between swallowing and respiration may cause severe respiratory disorders such as aspiration pneumonia, understanding the neuronal mechanisms underlying such coordination is important. Recently, it was reported that medullary noradrenergic neurons are involved in evoking esophageal-gastric relaxation reflex, leading to a hypothesis that such neurons are also involved in swallowing-respiration coordination. We tested this hypothesis using an in vitro brain-stem preparation obtained from neonatal rats. A temporal inhibition of respiratory rhythm was consistently observed when swallowing activity was induced by electrical stimulations to the supralaryngeal nerve. We found that a broad adrenergic receptor agonist, norepinephrine, markedly blocked the swallowing-induced temporal inhibition of respiration. Further studies revealed that swallowing-induced respiratory inhibition is blocked by an α2-adrenergic receptor agonist and enhanced by an α2-adrenergic receptor antagonist, indicating an important role of α2-adrenergic receptors in regulation of the coordination between swallowing and respiration in vitro. |
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Recently, it was reported that medullary noradrenergic neurons are involved in evoking esophageal-gastric relaxation reflex, leading to a hypothesis that such neurons are also involved in swallowing-respiration coordination. We tested this hypothesis using an in vitro brain-stem preparation obtained from neonatal rats. A temporal inhibition of respiratory rhythm was consistently observed when swallowing activity was induced by electrical stimulations to the supralaryngeal nerve. We found that a broad adrenergic receptor agonist, norepinephrine, markedly blocked the swallowing-induced temporal inhibition of respiration. Further studies revealed that swallowing-induced respiratory inhibition is blocked by an α2-adrenergic receptor agonist and enhanced by an α2-adrenergic receptor antagonist, indicating an important role of α2-adrenergic receptors in regulation of the coordination between swallowing and respiration in vitro.</description><identifier>ISSN: 0022-0345</identifier><identifier>EISSN: 1544-0591</identifier><identifier>DOI: 10.1177/0022034509360312</identifier><language>eng</language><publisher>Washington, DC: SAGE Publications</publisher><subject>Adrenergic receptors ; Agonists ; Biological and medical sciences ; Brain stem ; Cardiorespiratory control. Arterial mecano- and chemoreceptor ; Digital audio tape ; Drugs ; Electrical stimuli ; Esophagus ; Fundamental and applied biological sciences. Psychology ; Hypotheses ; Neonates ; Norepinephrine ; Respiration ; Rhythm ; Spinal cord ; Swallowing ; Vertebrates: respiratory system</subject><ispartof>Journal of dental research, 2010-03, Vol.89 (3), p.258-263</ispartof><rights>2010 International & American Associations for Dental Research</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-84bf5d25e9ee70f000176692d90dff3aa3e7125d7616b4351b5df49e715ac1ff3</citedby><cites>FETCH-LOGICAL-c349t-84bf5d25e9ee70f000176692d90dff3aa3e7125d7616b4351b5df49e715ac1ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0022034509360312$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0022034509360312$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21818,27923,27924,43620,43621</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22518907$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamanishi, T.</creatorcontrib><creatorcontrib>Takao, K.</creatorcontrib><creatorcontrib>Koizumi, H.</creatorcontrib><creatorcontrib>Ishihama, K.</creatorcontrib><creatorcontrib>Nohara, K.</creatorcontrib><creatorcontrib>Komaki, M.</creatorcontrib><creatorcontrib>Enomoto, A.</creatorcontrib><creatorcontrib>Yokota, Y.</creatorcontrib><creatorcontrib>Kogo, M.</creatorcontrib><title>α2-Adrenoceptors Coordinate Swallowing and Respiration</title><title>Journal of dental research</title><addtitle>J Dent Res</addtitle><description>Because the discoordination between swallowing and respiration may cause severe respiratory disorders such as aspiration pneumonia, understanding the neuronal mechanisms underlying such coordination is important. Recently, it was reported that medullary noradrenergic neurons are involved in evoking esophageal-gastric relaxation reflex, leading to a hypothesis that such neurons are also involved in swallowing-respiration coordination. We tested this hypothesis using an in vitro brain-stem preparation obtained from neonatal rats. A temporal inhibition of respiratory rhythm was consistently observed when swallowing activity was induced by electrical stimulations to the supralaryngeal nerve. We found that a broad adrenergic receptor agonist, norepinephrine, markedly blocked the swallowing-induced temporal inhibition of respiration. Further studies revealed that swallowing-induced respiratory inhibition is blocked by an α2-adrenergic receptor agonist and enhanced by an α2-adrenergic receptor antagonist, indicating an important role of α2-adrenergic receptors in regulation of the coordination between swallowing and respiration in vitro.</description><subject>Adrenergic receptors</subject><subject>Agonists</subject><subject>Biological and medical sciences</subject><subject>Brain stem</subject><subject>Cardiorespiratory control. Arterial mecano- and chemoreceptor</subject><subject>Digital audio tape</subject><subject>Drugs</subject><subject>Electrical stimuli</subject><subject>Esophagus</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypotheses</subject><subject>Neonates</subject><subject>Norepinephrine</subject><subject>Respiration</subject><subject>Rhythm</subject><subject>Spinal cord</subject><subject>Swallowing</subject><subject>Vertebrates: respiratory system</subject><issn>0022-0345</issn><issn>1544-0591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kEtLxDAUhYMoWEf3LgviMnrzaprlUHzBgOBjXTJNMnSoSU06DP4s_4i_yZYZFARXF-75zjlwEDoncEWIlNcAlALjAhQrgBF6gDIiOMcgFDlE2STjST9GJymtAYiiJcuQ_PqkeG6i9aGx_RBiyqsQomm9Hmz-vNVdF7atX-Xam_zJpr6NemiDP0VHTnfJnu3vDL3e3rxU93jxePdQzRe4YVwNuORLJwwVVlkrwcHYK4tCUaPAOMe0ZlYSKowsSLHkTJClMI6r8Sl0Q0Zihi52uX0M7xubhnodNtGPlTVlAKKkrJAjBTuqiSGlaF3dx_ZNx4-aQD3NU_-dZ7Rc7oN1anTnovZNm358lApSKpii8Y5LemV_y__N_QbZunBl</recordid><startdate>201003</startdate><enddate>201003</enddate><creator>Yamanishi, T.</creator><creator>Takao, K.</creator><creator>Koizumi, H.</creator><creator>Ishihama, K.</creator><creator>Nohara, K.</creator><creator>Komaki, M.</creator><creator>Enomoto, A.</creator><creator>Yokota, Y.</creator><creator>Kogo, M.</creator><general>SAGE Publications</general><general>International Association for Dental Research</general><general>SAGE PUBLICATIONS, INC</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>U9A</scope></search><sort><creationdate>201003</creationdate><title>α2-Adrenoceptors Coordinate Swallowing and Respiration</title><author>Yamanishi, T. ; Takao, K. ; Koizumi, H. ; Ishihama, K. ; Nohara, K. ; Komaki, M. ; Enomoto, A. ; Yokota, Y. ; Kogo, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-84bf5d25e9ee70f000176692d90dff3aa3e7125d7616b4351b5df49e715ac1ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adrenergic receptors</topic><topic>Agonists</topic><topic>Biological and medical sciences</topic><topic>Brain stem</topic><topic>Cardiorespiratory control. Arterial mecano- and chemoreceptor</topic><topic>Digital audio tape</topic><topic>Drugs</topic><topic>Electrical stimuli</topic><topic>Esophagus</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypotheses</topic><topic>Neonates</topic><topic>Norepinephrine</topic><topic>Respiration</topic><topic>Rhythm</topic><topic>Spinal cord</topic><topic>Swallowing</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamanishi, T.</creatorcontrib><creatorcontrib>Takao, K.</creatorcontrib><creatorcontrib>Koizumi, H.</creatorcontrib><creatorcontrib>Ishihama, K.</creatorcontrib><creatorcontrib>Nohara, K.</creatorcontrib><creatorcontrib>Komaki, M.</creatorcontrib><creatorcontrib>Enomoto, A.</creatorcontrib><creatorcontrib>Yokota, Y.</creatorcontrib><creatorcontrib>Kogo, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>ProQuest Nursing and Allied Health Source</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><jtitle>Journal of dental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamanishi, T.</au><au>Takao, K.</au><au>Koizumi, H.</au><au>Ishihama, K.</au><au>Nohara, K.</au><au>Komaki, M.</au><au>Enomoto, A.</au><au>Yokota, Y.</au><au>Kogo, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>α2-Adrenoceptors Coordinate Swallowing and Respiration</atitle><jtitle>Journal of dental research</jtitle><addtitle>J Dent Res</addtitle><date>2010-03</date><risdate>2010</risdate><volume>89</volume><issue>3</issue><spage>258</spage><epage>263</epage><pages>258-263</pages><issn>0022-0345</issn><eissn>1544-0591</eissn><abstract>Because the discoordination between swallowing and respiration may cause severe respiratory disorders such as aspiration pneumonia, understanding the neuronal mechanisms underlying such coordination is important. Recently, it was reported that medullary noradrenergic neurons are involved in evoking esophageal-gastric relaxation reflex, leading to a hypothesis that such neurons are also involved in swallowing-respiration coordination. We tested this hypothesis using an in vitro brain-stem preparation obtained from neonatal rats. A temporal inhibition of respiratory rhythm was consistently observed when swallowing activity was induced by electrical stimulations to the supralaryngeal nerve. We found that a broad adrenergic receptor agonist, norepinephrine, markedly blocked the swallowing-induced temporal inhibition of respiration. Further studies revealed that swallowing-induced respiratory inhibition is blocked by an α2-adrenergic receptor agonist and enhanced by an α2-adrenergic receptor antagonist, indicating an important role of α2-adrenergic receptors in regulation of the coordination between swallowing and respiration in vitro.</abstract><cop>Washington, DC</cop><pub>SAGE Publications</pub><doi>10.1177/0022034509360312</doi><tpages>6</tpages></addata></record> |
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subjects | Adrenergic receptors Agonists Biological and medical sciences Brain stem Cardiorespiratory control. Arterial mecano- and chemoreceptor Digital audio tape Drugs Electrical stimuli Esophagus Fundamental and applied biological sciences. Psychology Hypotheses Neonates Norepinephrine Respiration Rhythm Spinal cord Swallowing Vertebrates: respiratory system |
title | α2-Adrenoceptors Coordinate Swallowing and Respiration |
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