α2-Adrenoceptors Coordinate Swallowing and Respiration

Because the discoordination between swallowing and respiration may cause severe respiratory disorders such as aspiration pneumonia, understanding the neuronal mechanisms underlying such coordination is important. Recently, it was reported that medullary noradrenergic neurons are involved in evoking...

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Veröffentlicht in:Journal of dental research 2010-03, Vol.89 (3), p.258-263
Hauptverfasser: Yamanishi, T., Takao, K., Koizumi, H., Ishihama, K., Nohara, K., Komaki, M., Enomoto, A., Yokota, Y., Kogo, M.
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container_end_page 263
container_issue 3
container_start_page 258
container_title Journal of dental research
container_volume 89
creator Yamanishi, T.
Takao, K.
Koizumi, H.
Ishihama, K.
Nohara, K.
Komaki, M.
Enomoto, A.
Yokota, Y.
Kogo, M.
description Because the discoordination between swallowing and respiration may cause severe respiratory disorders such as aspiration pneumonia, understanding the neuronal mechanisms underlying such coordination is important. Recently, it was reported that medullary noradrenergic neurons are involved in evoking esophageal-gastric relaxation reflex, leading to a hypothesis that such neurons are also involved in swallowing-respiration coordination. We tested this hypothesis using an in vitro brain-stem preparation obtained from neonatal rats. A temporal inhibition of respiratory rhythm was consistently observed when swallowing activity was induced by electrical stimulations to the supralaryngeal nerve. We found that a broad adrenergic receptor agonist, norepinephrine, markedly blocked the swallowing-induced temporal inhibition of respiration. Further studies revealed that swallowing-induced respiratory inhibition is blocked by an α2-adrenergic receptor agonist and enhanced by an α2-adrenergic receptor antagonist, indicating an important role of α2-adrenergic receptors in regulation of the coordination between swallowing and respiration in vitro.
doi_str_mv 10.1177/0022034509360312
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subjects Adrenergic receptors
Agonists
Biological and medical sciences
Brain stem
Cardiorespiratory control. Arterial mecano- and chemoreceptor
Digital audio tape
Drugs
Electrical stimuli
Esophagus
Fundamental and applied biological sciences. Psychology
Hypotheses
Neonates
Norepinephrine
Respiration
Rhythm
Spinal cord
Swallowing
Vertebrates: respiratory system
title α2-Adrenoceptors Coordinate Swallowing and Respiration
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