Lycobetaine acts as a selective topoisomerase II[beta] poison and inhibits the growth of human tumour cells

The phenanthridine alkaloid lycobetaine is a minor constituent of Amaryllidaceae. Inhibition of cell growth was studied in the clonogenic assay on 21 human tumour xenografts (mean IC(50) = 0.8 microM). The growth of human leukaemia cell lines was also potently inhibited (mean IC(50) = 1.3 microM). A...

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Veröffentlicht in:	British journal of cancer 2001-11, Vol.85 (10), p.1585
Hauptverfasser:	Barthelmes, H U, Niederberger, E, Roth, T, Schulte, K, Tang, W C, Boege, F, H-H Fiebig, Eisenbrand, G, Marko, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Ascites Cancer research Cells Flow cytometry Gastric cancer Medical research Penicillin Tumors
Online-Zugang:	Volltext
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