Lactate levels in Asian patients with type 2 diabetes mellitus on metformin and its association with dose of metformin and renal function
Summary Aim: Our aims are to discover the average fasting plasma lactate level (FPL) in Asian patients with type 2 diabetes mellitus on metformin, with or without renal impairment and whether FPL is associated with the total daily dose of metformin (Tmet) and the degree of renal impairment in these...
Gespeichert in:
| Veröffentlicht in: | International journal of clinical practice (Esher) 2007-11, Vol.61 (11), p.1829-1833 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1833 |
|---|---|
| container_issue | 11 |
| container_start_page | 1829 |
| container_title | International journal of clinical practice (Esher) |
| container_volume | 61 |
| creator | Lim, Vivien C. C. Sum, C. F. Chan, Edwin S. Y. Yeoh, L. Y. Lee, Y. M. Lim, S. C. |
| description | Summary
Aim: Our aims are to discover the average fasting plasma lactate level (FPL) in Asian patients with type 2 diabetes mellitus on metformin, with or without renal impairment and whether FPL is associated with the total daily dose of metformin (Tmet) and the degree of renal impairment in these patients.
Methods: We conducted an observational cross‐sectional study of Asian patients with type 2 diabetes, using measurements of FPL levels and glomerular filtration rate (GFR) calculated, using the abbreviated modification of diet in renal disease (MDRD) formula. The association between FPL, Tmet, GFR and other potential predictors was analysed.
Results: A total of 97 subjects were recruited from our diabetes centre between July 2005 and February 2006. Sixty (61.9%) of the subjects were males; 69 (71.1%) Chinese, 21 (21.6%) Malays and 6 (6.2%) Indians. The mean (SD) age was 58.8 years (10.7) and the mean body mass index was 27.1 kg/m2 (5.3). The mean FPL was 1.8 mmol/l (0.9) with 20 (20.6%) of subjects having an FPL beyond the upper limit of our reference range of 2.2 mmol/l.
The mean FPL (two SE) of subjects with Tmet of ≤ 1000, 1001–2000 and > 2000 mg were 1.7 mmol/l (0.2), 1.6 mmol/l (0.2) and 2.1 mmol/l (0.5) respectively, (p = 0.119). The mean FPL of subjects with GFR of 90 ml/min/1.73 m2 was 1.7 mmol/l (0.3), 1.8 mmol/l (0.3) and 1.8 mmol/l (0.4) respectively, p = 0.757. Among the potential predictors analysed, aspartate transaminase (p = 0.001) was found to be significantly associated with FPL.
Conclusions: Our study shows no correlation between Tmet and GFR with FPL in Asian type 2 diabetic patients on metformin. |
| doi_str_mv | 10.1111/j.1742-1241.2007.01487.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_journals_229937335</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1556875921</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4647-3c220dd1fcea044b122e2bf201c33137ea42d5f9f74a2093f2f14f27ae4bc1d3</originalsourceid><addsrcrecordid>eNpdkdGK1DAYhYMo7rr6ChIEL1uTP-mkuRGWUcd1BxVZ8DKk6R_M2GnHJnVnHsG3Nt0Zd8Hc5MD5ziHkEEI5K3k-bzYlVxIKDpKXwJgqGZe1KvePyPm98ThrsaiLigl-Rp7FuGEMqqpmT8kZV3WttK7OyZ-1dckmpB3-xi7S0NPLGGxPdzYF7FOktyH9oOmwQwq0DbbBhJFusetCmiId-qyTH8ZtTtq-pSFHbIyDC7kgu3fxdohIB_8fOmJvO-qn3s3kc_LE2y7ii9N9QW4-vL9ZfizWX1ZXy8t14eRCqkI4ANa23Du0TMqGAyA0Hhh3QnCh0EpoK6-9khaYFh48lx6URdk43ooL8upYuxuHXxPGZDbDNOaHRAOgtVBCVBl6eYKmZout2Y1ha8eD-fdvGXh9Amx0tvOj7V2ID5zOM2gtM_f2yN2GDg8PPjPzjmZj5rnMPJeZdzR3O5q9ufq0_DrLXFAcC0JMuL8vsONPs1BCVeb755W5_sav34kVGCn-AmdEoV0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>229937335</pqid></control><display><type>article</type><title>Lactate levels in Asian patients with type 2 diabetes mellitus on metformin and its association with dose of metformin and renal function</title><source>Wiley-Blackwell Journals</source><source>MEDLINE</source><creator>Lim, Vivien C. C. ; Sum, C. F. ; Chan, Edwin S. Y. ; Yeoh, L. Y. ; Lee, Y. M. ; Lim, S. C.</creator><creatorcontrib>Lim, Vivien C. C. ; Sum, C. F. ; Chan, Edwin S. Y. ; Yeoh, L. Y. ; Lee, Y. M. ; Lim, S. C.</creatorcontrib><description>Summary
Aim: Our aims are to discover the average fasting plasma lactate level (FPL) in Asian patients with type 2 diabetes mellitus on metformin, with or without renal impairment and whether FPL is associated with the total daily dose of metformin (Tmet) and the degree of renal impairment in these patients.
Methods: We conducted an observational cross‐sectional study of Asian patients with type 2 diabetes, using measurements of FPL levels and glomerular filtration rate (GFR) calculated, using the abbreviated modification of diet in renal disease (MDRD) formula. The association between FPL, Tmet, GFR and other potential predictors was analysed.
Results: A total of 97 subjects were recruited from our diabetes centre between July 2005 and February 2006. Sixty (61.9%) of the subjects were males; 69 (71.1%) Chinese, 21 (21.6%) Malays and 6 (6.2%) Indians. The mean (SD) age was 58.8 years (10.7) and the mean body mass index was 27.1 kg/m2 (5.3). The mean FPL was 1.8 mmol/l (0.9) with 20 (20.6%) of subjects having an FPL beyond the upper limit of our reference range of 2.2 mmol/l.
The mean FPL (two SE) of subjects with Tmet of ≤ 1000, 1001–2000 and > 2000 mg were 1.7 mmol/l (0.2), 1.6 mmol/l (0.2) and 2.1 mmol/l (0.5) respectively, (p = 0.119). The mean FPL of subjects with GFR of < 60, 60–90 and > 90 ml/min/1.73 m2 was 1.7 mmol/l (0.3), 1.8 mmol/l (0.3) and 1.8 mmol/l (0.4) respectively, p = 0.757. Among the potential predictors analysed, aspartate transaminase (p = 0.001) was found to be significantly associated with FPL.
Conclusions: Our study shows no correlation between Tmet and GFR with FPL in Asian type 2 diabetic patients on metformin.</description><identifier>ISSN: 1368-5031</identifier><identifier>EISSN: 1742-1241</identifier><identifier>DOI: 10.1111/j.1742-1241.2007.01487.x</identifier><identifier>PMID: 17887995</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acidosis, Lactic - chemically induced ; Asia - ethnology ; Asian people ; Biological and medical sciences ; Cross-Sectional Studies ; Diabetes ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - ethnology ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Diabetic Nephropathies - ethnology ; Diabetic Nephropathies - physiopathology ; Drug dosages ; Drug therapy ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; General aspects ; Glomerular Filtration Rate - physiology ; Humans ; Hypoglycemic Agents - adverse effects ; Lactic Acid - blood ; Male ; Medical sciences ; Metabolism ; Metformin - adverse effects ; Middle Aged ; Prescription drugs</subject><ispartof>International journal of clinical practice (Esher), 2007-11, Vol.61 (11), p.1829-1833</ispartof><rights>2007 INIST-CNRS</rights><rights>2007 The Authors Journal compilation 2007 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4647-3c220dd1fcea044b122e2bf201c33137ea42d5f9f74a2093f2f14f27ae4bc1d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1742-1241.2007.01487.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1742-1241.2007.01487.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19174994$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17887995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lim, Vivien C. C.</creatorcontrib><creatorcontrib>Sum, C. F.</creatorcontrib><creatorcontrib>Chan, Edwin S. Y.</creatorcontrib><creatorcontrib>Yeoh, L. Y.</creatorcontrib><creatorcontrib>Lee, Y. M.</creatorcontrib><creatorcontrib>Lim, S. C.</creatorcontrib><title>Lactate levels in Asian patients with type 2 diabetes mellitus on metformin and its association with dose of metformin and renal function</title><title>International journal of clinical practice (Esher)</title><addtitle>Int J Clin Pract</addtitle><description>Summary
Aim: Our aims are to discover the average fasting plasma lactate level (FPL) in Asian patients with type 2 diabetes mellitus on metformin, with or without renal impairment and whether FPL is associated with the total daily dose of metformin (Tmet) and the degree of renal impairment in these patients.
Methods: We conducted an observational cross‐sectional study of Asian patients with type 2 diabetes, using measurements of FPL levels and glomerular filtration rate (GFR) calculated, using the abbreviated modification of diet in renal disease (MDRD) formula. The association between FPL, Tmet, GFR and other potential predictors was analysed.
Results: A total of 97 subjects were recruited from our diabetes centre between July 2005 and February 2006. Sixty (61.9%) of the subjects were males; 69 (71.1%) Chinese, 21 (21.6%) Malays and 6 (6.2%) Indians. The mean (SD) age was 58.8 years (10.7) and the mean body mass index was 27.1 kg/m2 (5.3). The mean FPL was 1.8 mmol/l (0.9) with 20 (20.6%) of subjects having an FPL beyond the upper limit of our reference range of 2.2 mmol/l.
The mean FPL (two SE) of subjects with Tmet of ≤ 1000, 1001–2000 and > 2000 mg were 1.7 mmol/l (0.2), 1.6 mmol/l (0.2) and 2.1 mmol/l (0.5) respectively, (p = 0.119). The mean FPL of subjects with GFR of < 60, 60–90 and > 90 ml/min/1.73 m2 was 1.7 mmol/l (0.3), 1.8 mmol/l (0.3) and 1.8 mmol/l (0.4) respectively, p = 0.757. Among the potential predictors analysed, aspartate transaminase (p = 0.001) was found to be significantly associated with FPL.
Conclusions: Our study shows no correlation between Tmet and GFR with FPL in Asian type 2 diabetic patients on metformin.</description><subject>Acidosis, Lactic - chemically induced</subject><subject>Asia - ethnology</subject><subject>Asian people</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - ethnology</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic Nephropathies - ethnology</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>General aspects</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Humans</subject><subject>Hypoglycemic Agents - adverse effects</subject><subject>Lactic Acid - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Metformin - adverse effects</subject><subject>Middle Aged</subject><subject>Prescription drugs</subject><issn>1368-5031</issn><issn>1742-1241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdGK1DAYhYMo7rr6ChIEL1uTP-mkuRGWUcd1BxVZ8DKk6R_M2GnHJnVnHsG3Nt0Zd8Hc5MD5ziHkEEI5K3k-bzYlVxIKDpKXwJgqGZe1KvePyPm98ThrsaiLigl-Rp7FuGEMqqpmT8kZV3WttK7OyZ-1dckmpB3-xi7S0NPLGGxPdzYF7FOktyH9oOmwQwq0DbbBhJFusetCmiId-qyTH8ZtTtq-pSFHbIyDC7kgu3fxdohIB_8fOmJvO-qn3s3kc_LE2y7ii9N9QW4-vL9ZfizWX1ZXy8t14eRCqkI4ANa23Du0TMqGAyA0Hhh3QnCh0EpoK6-9khaYFh48lx6URdk43ooL8upYuxuHXxPGZDbDNOaHRAOgtVBCVBl6eYKmZout2Y1ha8eD-fdvGXh9Amx0tvOj7V2ID5zOM2gtM_f2yN2GDg8PPjPzjmZj5rnMPJeZdzR3O5q9ufq0_DrLXFAcC0JMuL8vsONPs1BCVeb755W5_sav34kVGCn-AmdEoV0</recordid><startdate>200711</startdate><enddate>200711</enddate><creator>Lim, Vivien C. C.</creator><creator>Sum, C. F.</creator><creator>Chan, Edwin S. Y.</creator><creator>Yeoh, L. Y.</creator><creator>Lee, Y. M.</creator><creator>Lim, S. C.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Hindawi Limited</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>200711</creationdate><title>Lactate levels in Asian patients with type 2 diabetes mellitus on metformin and its association with dose of metformin and renal function</title><author>Lim, Vivien C. C. ; Sum, C. F. ; Chan, Edwin S. Y. ; Yeoh, L. Y. ; Lee, Y. M. ; Lim, S. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4647-3c220dd1fcea044b122e2bf201c33137ea42d5f9f74a2093f2f14f27ae4bc1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acidosis, Lactic - chemically induced</topic><topic>Asia - ethnology</topic><topic>Asian people</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - ethnology</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic Nephropathies - ethnology</topic><topic>Diabetic Nephropathies - physiopathology</topic><topic>Drug dosages</topic><topic>Drug therapy</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>General aspects</topic><topic>Glomerular Filtration Rate - physiology</topic><topic>Humans</topic><topic>Hypoglycemic Agents - adverse effects</topic><topic>Lactic Acid - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Metformin - adverse effects</topic><topic>Middle Aged</topic><topic>Prescription drugs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lim, Vivien C. C.</creatorcontrib><creatorcontrib>Sum, C. F.</creatorcontrib><creatorcontrib>Chan, Edwin S. Y.</creatorcontrib><creatorcontrib>Yeoh, L. Y.</creatorcontrib><creatorcontrib>Lee, Y. M.</creatorcontrib><creatorcontrib>Lim, S. C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>International journal of clinical practice (Esher)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lim, Vivien C. C.</au><au>Sum, C. F.</au><au>Chan, Edwin S. Y.</au><au>Yeoh, L. Y.</au><au>Lee, Y. M.</au><au>Lim, S. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lactate levels in Asian patients with type 2 diabetes mellitus on metformin and its association with dose of metformin and renal function</atitle><jtitle>International journal of clinical practice (Esher)</jtitle><addtitle>Int J Clin Pract</addtitle><date>2007-11</date><risdate>2007</risdate><volume>61</volume><issue>11</issue><spage>1829</spage><epage>1833</epage><pages>1829-1833</pages><issn>1368-5031</issn><eissn>1742-1241</eissn><abstract>Summary
Aim: Our aims are to discover the average fasting plasma lactate level (FPL) in Asian patients with type 2 diabetes mellitus on metformin, with or without renal impairment and whether FPL is associated with the total daily dose of metformin (Tmet) and the degree of renal impairment in these patients.
Methods: We conducted an observational cross‐sectional study of Asian patients with type 2 diabetes, using measurements of FPL levels and glomerular filtration rate (GFR) calculated, using the abbreviated modification of diet in renal disease (MDRD) formula. The association between FPL, Tmet, GFR and other potential predictors was analysed.
Results: A total of 97 subjects were recruited from our diabetes centre between July 2005 and February 2006. Sixty (61.9%) of the subjects were males; 69 (71.1%) Chinese, 21 (21.6%) Malays and 6 (6.2%) Indians. The mean (SD) age was 58.8 years (10.7) and the mean body mass index was 27.1 kg/m2 (5.3). The mean FPL was 1.8 mmol/l (0.9) with 20 (20.6%) of subjects having an FPL beyond the upper limit of our reference range of 2.2 mmol/l.
The mean FPL (two SE) of subjects with Tmet of ≤ 1000, 1001–2000 and > 2000 mg were 1.7 mmol/l (0.2), 1.6 mmol/l (0.2) and 2.1 mmol/l (0.5) respectively, (p = 0.119). The mean FPL of subjects with GFR of < 60, 60–90 and > 90 ml/min/1.73 m2 was 1.7 mmol/l (0.3), 1.8 mmol/l (0.3) and 1.8 mmol/l (0.4) respectively, p = 0.757. Among the potential predictors analysed, aspartate transaminase (p = 0.001) was found to be significantly associated with FPL.
Conclusions: Our study shows no correlation between Tmet and GFR with FPL in Asian type 2 diabetic patients on metformin.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17887995</pmid><doi>10.1111/j.1742-1241.2007.01487.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1368-5031 |
| ispartof | International journal of clinical practice (Esher), 2007-11, Vol.61 (11), p.1829-1833 |
| issn | 1368-5031 1742-1241 |
| language | eng |
| recordid | cdi_proquest_journals_229937335 |
| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Acidosis, Lactic - chemically induced Asia - ethnology Asian people Biological and medical sciences Cross-Sectional Studies Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Diabetic Nephropathies - ethnology Diabetic Nephropathies - physiopathology Drug dosages Drug therapy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female General aspects Glomerular Filtration Rate - physiology Humans Hypoglycemic Agents - adverse effects Lactic Acid - blood Male Medical sciences Metabolism Metformin - adverse effects Middle Aged Prescription drugs |
| title | Lactate levels in Asian patients with type 2 diabetes mellitus on metformin and its association with dose of metformin and renal function |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T08%3A34%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lactate%20levels%20in%20Asian%20patients%20with%20type%202%20diabetes%20mellitus%20on%20metformin%20and%20its%20association%20with%20dose%20of%20metformin%20and%20renal%20function&rft.jtitle=International%20journal%20of%20clinical%20practice%20(Esher)&rft.au=Lim,%20Vivien%20C.%20C.&rft.date=2007-11&rft.volume=61&rft.issue=11&rft.spage=1829&rft.epage=1833&rft.pages=1829-1833&rft.issn=1368-5031&rft.eissn=1742-1241&rft_id=info:doi/10.1111/j.1742-1241.2007.01487.x&rft_dat=%3Cproquest_pubme%3E1556875921%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=229937335&rft_id=info:pmid/17887995&rfr_iscdi=true |