Modified benzoxazolone (ABO‐AA) based single photon emission computed tomography (SPECT) probes for 18 kDa translocator protein

Acetamidobenzoxazolone (ABO) has been modified to ABO‐AA, 2‐(2‐(5‐bromo/chloro benzoxazolone)acetamide)‐3‐(1H‐indol‐3‐yl)propionate to improve pharmacokinetics and lipophilicity (log p = 2.04). The final compound was synthesized in better yield and in fewer steps than previously reported MBIP‐Br (70...

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Veröffentlicht in:	Drug development research 2019-09, Vol.80 (6), p.741-749
Hauptverfasser:	Srivastava, Pooja, Kakkar, Dipti, Kumar, Pravir, Tiwari, Anjani Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells acetamidobenzoxazolone Animals Benzoxazoles Computation Computed tomography Computer applications Diodes Fluorescent Dyes Humans inflammation Inflammation - chemically induced Inflammation - diagnostic imaging Inflammation - metabolism Lipophilicity Lipopolysaccharides Lung Diseases - chemically induced Lung Diseases - diagnostic imaging Lung Diseases - metabolism Male Mice, Inbred BALB C Organs Pharmacokinetics Photon emission Photons Propionic acid Proteins Rabbits Radioligand Assay Receptors, GABA - metabolism Scintigraphy Single photon emission computed tomography SPECT Technetium Tomography Tomography, Emission-Computed, Single-Photon tryptophan methyl ester TSPO
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