5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR) stimulates myocardial glycogenolysis by allosteric mechanisms

We tested the hypothesis that activation of AMP-activated protein kinase (AMPK) promotes myocardial glycogenolysis by decreasing glycogen synthase (GS) and/or increasing glycogen phosphorylase (GP) activities. Isolated working hearts from halothane-anesthetized male Sprague-Dawley rats perfused in t...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2003-04, Vol.53 (4), p.R936
Hauptverfasser:	Longnus, Sarah L, Wambolt, Richard B, Parsons, Hannah L, Brownsey, Roger W, Allard, Michael F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Carbon Cardiovascular disease
Online-Zugang:	Volltext
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